Material Safety Data Sheet: 8-Hydroxyquinoline Citrate

Identification

Product Name: 8-Hydroxyquinoline Citrate
Chemical Family: Quinoline derivatives
Synonyms: 8-Quinolinol, citrate salt
CAS Number: 148-17-0
Intended Use: Research, laboratory, and specialized industrial processes
Supplier Details: [Company Name], [Address], [Phone Number], [Email]
Emergency Contact: [24-hour emergency number for chemical emergencies]

Hazard Identification

Classification: Skin and eye irritant, harmful if swallowed, may cause respiratory irritation
Signal Word: Warning
Hazard Statements: Causes serious eye damage, may cause skin irritation, can be harmful if inhaled or ingested
Pictograms: Exclamation mark (GHS07), Corrosion (GHS05)
Precautionary Statements: Avoid breathing dust, wear eye protection, wash hands thoroughly after handling, do not eat or drink when using this chemical

Composition / Information on Ingredients

Chemical Name: 8-Hydroxyquinoline Citrate
Formula: C9H7NO.C6H8O7
CAS Number: 148-17-0
Concentration: >97% (remainder as impurities and hydration)
Other Constituents: Trace moisture, no added stabilizers or preservatives

First Aid Measures

Eye Contact: Rinse immediately under running water for 15 minutes, lift eyelids, remove contact lenses, seek medical help
Skin Contact: Wash with soap and plenty of water, remove contaminated clothing, medical advice if irritation persists
Inhalation: Move to fresh air, keep at rest, get advice if symptoms develop (e.g., coughing, shortness of breath)
Ingestion: Rinse mouth, do not induce vomiting, give water if alert, immediate medical attention required
Most Important Symptoms: Irritation of eyes, respiratory symptoms like coughing, nausea, skin redness or rash
Notes for Physicians: Treat symptomatically, monitor for complications such as respiratory distress or chemical burns

Fire-Fighting Measures

Suitable Extinguishing Media: Water spray, dry powder, carbon dioxide, foam
Unsuitable Media: None known for this material (do not use high pressure water jet)
Specific Hazards: May emit toxic fumes of nitrogen oxides, carbon dioxide, and carbon monoxide during combustion
Protective Equipment: Self-contained breathing apparatus and full protective gear
Additional Advice: Remove container from fire area if safe, cool exposed containers with water

Accidental Release Measures

Personal Precautions: Ventilate area, avoid dust formation, use protective gloves, goggles, dust mask
Environmental Precautions: Avoid contamination of water bodies, do not let large quantities enter drains
Method for Cleanup: Sweep up into container for disposal, clean surface with damp cloth, ventilate the area, avoid raising dust, use antistatic tools

Handling and Storage

Handling: Work in ventilated space, wear protective equipment, do not handle until safety procedures are clear, avoid direct contact
Storage: Keep container tightly closed, store in dry, well-ventilated area between 2–8°C, protect from direct light, store away from acids, oxidizers, food, and drink
Hygiene Practices: Wash hands after use, remove contaminated clothing, prevent ingestion and inhalation during transfer or weighing

Exposure Controls and Personal Protection

Exposure Limits: No US OSHA or ACGIH limits set, use controls to keep exposure as low as possible
Engineering Controls: Chemical fume hood or equivalent local exhaust ventilation
Personal Protection: Chemical-resistant gloves (nitrile), splash goggles, laboratory coat, dust mask or respirator (NIOSH approved if dusting)
General Safety: Emergency shower and eyewash station near use area, do not eat, drink, or smoke in work areas

Physical and Chemical Properties

Appearance: Fine, off-white or pale yellow powder
Odor: Slight, phenolic odor
Molecular Weight: 355.31 g/mol
Melting Point: 186–190°C (decomposes)
Solubility: Soluble in water, soluble in ethanol and methanol
pH (1% solution): 3.0–4.5
Boiling Point: Not applicable (decomposes before boiling)
Vapor Pressure: Not measurable at room temperature
Flash Point: Not applicable
Density: Approximately 1.5 g/cm³

Stability and Reactivity

Chemical Stability: Stable under recommended storage conditions
Reactive Materials: Reacts with strong oxidizing agents, acids, alkalis
Decomposition Products: Under fire or heat, emits carbon oxides, nitrogen oxides
Conditions to Avoid: Moisture, high heat, prolonged exposure to air, incompatible materials
Polymerization: No hazardous polymerization expected

Toxicological Information

Likely Routes of Exposure: Inhalation, skin, eyes, ingestion
Acute Effects: Eye and skin irritation, nausea, headache, coughing, abdominal pain
Chronic Effects: Prolonged or repeated exposure may cause liver, kidney or nerve damage (based on analogues)
LD50 (oral, rat): Estimated at 1800 mg/kg
Skin Sensitization: Possible with repeated contact
Carcinogenicity: Not listed by IARC, NTP, ACGIH, or OSHA
Other Data: No clear evidence of mutagenicity or reproductive toxicity, use caution due to limited studies

Ecological Information

Ecotoxicity: May be harmful to aquatic organisms, especially algae and daphnia in high concentrations
Persistence and Degradability: Moderate, slow breakdown in water and soil
Bioaccumulation Potential: Low to moderate (based on structure and similar substances)
Mobility in Soil: Slightly mobile, binds to organic matter
Other Harm: Avoid introduction into natural waterways or sewage systems in significant amounts

Disposal Considerations

Waste Disposal: Dispose as hazardous chemical waste according to local, state, or national regulations
Container Disposal: Rinse and triple-rinse, label as hazardous if contaminated, arrange for incineration or approved landfill
Precautions: Do not discharge to drains or environment, use licensed chemical waste contractor

Transport Information

UN Number: Not classified under UN Orange Book for transport
Transport Hazard Classification: Not classified as hazardous material for most shipping regulations (check for local exceptions)
Packing Group: Not assigned
Labeling Requirements: Standard chemical labeling, appropriate warnings for skin/eye irritant
Special Precautions: Ship in well-sealed, impact-resistant container, prevent moisture exposure

Regulatory Information

US TSCA: Listed
EU REACH: Pre-registered
Other Listings: Canada DSL/NDSL: Listed, Australia AICS: Listed, Japan ENCS: Listed
OSHA Classification: Hazardous
SARA Title III: Not a Section 302 or 313 chemical
California Prop 65: Not listed
WHMIS Classification: D2B (toxic material causing other toxic effects)
Other Regulations: Compliance with all workplace safety, storage, labeling, and transportation laws required