Product Name: Calcium Citrate Tetrahydrate
Chemical Formula: Ca₃(C₆H₅O₇)₂·4H₂O
CAS Number: 5785-44-4
EC Number: 212-391-7
Synonyms: Calcium 2-hydroxypropane-1,2,3-tricarboxylate, Tetrahydrate
Recommended Use: Nutritional supplement, food additive, laboratory reagent
Supplier Details: Supplier address, phone, and emergency contact information
GHS Classification: Not classified as hazardous under GHS
Signal Word: None
Hazard Statements: No significant hazards known. Dust may cause mild respiratory irritation. Prolonged contact with skin or eyes can cause minor irritation.
Precautionary Statements: Avoid breathing dust. Use personal protective equipment as described below. Wash hands after handling.
Other Hazards: Not considered to be environmentally hazardous. No evidence of carcinogenic, mutagenic, or reproductive toxicity effects as of current study data.
Substance: Pure substance
Chemical Name: Calcium Citrate Tetrahydrate
Concentration: 100%
CAS Number: 5785-44-4
Impurities/Additives: No significant impurities present at levels relevant to classification
Eye Contact: Rinse cautiously with water for several minutes. Remove contact lenses if present and easy to do. Continue rinsing. Seek medical advice if irritation develops or persists.
Skin Contact: Wash affected area thoroughly with soap and water. Remove contaminated clothing and wash before reuse. Seek medical attention for ongoing irritation.
Inhalation: Move to fresh air. If breathing difficulties arise, seek medical attention.
Ingestion: Rinse mouth with water. Seek medical attention in case of discomfort. No known acute effects expected from ingestion of small amounts.
Important Symptoms: Mild irritation to respiratory tract, skin, or eyes in sensitive individuals possible.
Medical Attention: No special measures required; treat symptomatically.
Suitable Extinguishing Media: Use water spray, dry chemical, carbon dioxide, or foam.
Unsuitable Media: No restrictions noted.
Fire/Explosion Hazards: Product is non-flammable and does not support combustion. No known risk of hazardous decomposition in a fire.
Protective Equipment: Firefighters should wear self-contained breathing apparatus and protective clothing to guard against possible toxic fumes from packaging or contaminants.
Combustion Products: Oxides of carbon and calcium, possible trace amounts of other irritating gases.
Personal Precautions: Avoid contact with eyes and skin. Avoid breathing dust. Use personal protective equipment as detailed below.
Spill Clean-Up: Sweep up material and place in a suitable container for disposal. Avoid generating dust. Wash spill area with water to remove any residue.
Environmental Precautions: Do not allow significant quantities to enter sewers or watercourses. Inform proper authorities in case of large accidental releases.
Methods for Containment: Prevent further leakage or spillage if safe to do so.
Handling: Handle with care to minimize dust generation. Maintain good industrial hygiene. Wash thoroughly after handling.
Storage Conditions: Store in a cool, dry, well-ventilated area in tightly closed containers. Protect from moisture and contamination. Keep away from incompatible substances, particularly strong acids.
Incompatible Materials: Strong acids or bases, oxidizing agents.
Other Precautions: Store away from food, drink, and animal feed.
Exposure Limits: No occupational exposure limits established for this substance.
Engineering Controls: Use adequate ventilation to minimize airborne dust. Local exhaust recommended for dusty operations.
Personal Protection: Safety glasses (EN166), gloves resistant to chemical agents, protective clothing if consistent exposure possible.
Respiratory Protection: Dust mask or respirator (EN149 or NIOSH N95) recommended for dusty conditions.
Environmental Exposure Controls: Prevent major releases to environment. Dispose of in accordance with local regulations.
Appearance: White, crystalline powder
Odor: Odorless
Odor Threshold: Not relevant
pH (1% solution): 6.5 – 8.5
Melting Point/Freezing Point: Decomposes before melting
Boiling Point: Not applicable
Flash Point: Not flammable
Evaporation Rate: Not applicable
Flammability: Non-flammable
Vapor Pressure: Not applicable
Vapor Density: Not applicable
Relative Density: ~2.4 g/cm3
Solubility: Slightly soluble in water; insoluble in alcohol
Partition Coefficient (n-octanol/water): Not determined
Auto-ignition Temperature: Not self-igniting
Decomposition Temperature: >220°C
Viscosity: Not applicable
Chemical Stability: Stable under normal storage and handling conditions.
Reactive Conditions: Exposure to strong acids may liberate citric acid and calcium ions.
Incompatibilities: Avoid contact with strong acids, oxidizers.
Hazardous Decomposition Products: Calcium oxides, carbon oxides on decomposition.
Polymerization: No risk of hazardous polymerization expected.
Acute Toxicity: No acute toxicity data available for humans; considered non-toxic at anticipated use levels.
Skin Corrosion/Irritation: Prolonged contact might cause mild irritation.
Eye Damage/Irritation: May cause mild mechanical irritation.
Inhalation: Inhalation of dust may cause minor respiratory tract irritation.
Ingestion: Used as a food additive; no significant toxicity reported in standard use.
Chronic Toxicity: No evidence for mutagenic, carcinogenic, or reproductive effects.
Additional Data: Not considered sensitizing. No data on aspiration hazards since substance is solid at ambient conditions.
Ecotoxicity: Not expected to pose significant risk to aquatic or terrestrial organisms.
Mobility in Soil: Low mobility due to low solubility in water.
Persistence/Degradability: Rapidly biodegradable; breaks down naturally to calcium and citrate ions in the environment.
Bioaccumulative Potential: Not expected to bioaccumulate.
Results of PBT and vPvB Assessment: Substance does not meet criteria for Persistent, Bioaccumulative and Toxic, or very Persistent and very Bioaccumulative.
Other Adverse Effects: Large releases could locally alter soil or water chemistry.
Waste Treatment Methods: Dispose of in accordance with local, regional, or national requirements. No special measures needed for small quantities. If disposed of as waste, landfill or incineration in an authorized facility is recommended.
Packaging Disposal: Rinse containers thoroughly before recycling or disposing. Contaminated packaging should be processed the same as the product.
Other Recommendations: Do not discharge to natural waterways or sewers in significant quantities.
UN Number: Not regulated
Proper Shipping Name: Calcium Citrate Tetrahydrate
Transport Hazard Class: Not applicable
Packing Group: Not applicable
Marine Pollutant: No
Special Precautions for Users: Ensure packaging is secure and undamaged to prevent spillage. No hazard label requirements. Comply with standard transport regulations for non-hazardous materials.
Land, Air, Sea Transport: No specific transport restrictions apply.
International Inventories: Listed in major chemical substance registries including TSCA (USA), EINECS/ELINCS (EU), DSL/NDSL (Canada), AICS (Australia), ENCS (Japan), and others.
Regulatory Status: Approved for use as a food additive in many countries (e.g., E333 in the EU). Regarded as Generally Recognized as Safe (GRAS) in the USA for intended uses.
Labeling Requirements: No hazard labeling required under GHS for supplied forms.
Other Regulatory Restrictions: Observe workplace exposure limits set for nuisance dust in applicable jurisdictions. Maintain standard protocols for chemical hygiene and food safety. All disposal and release must comply with local legislation.
Other Legal Requirements: No REACH registration required for substances of natural origin with established food uses.
