Product Name: Citric Acid Sodium Citrate Buffer
Other Names: Sodium citrate buffer, Citrate buffer
Recommended Use: Laboratory chemical, buffer solution for pH control in biological and chemical research
Supplier Details: [Supply information as per actual manufacturer]
Emergency Contact: [Provide contact number as per supplier policy]
Classification: Not classified as hazardous under GHS.
Signal Word: None
Hazard Statements: Dust may cause minor irritation to respiratory tract and eyes. Repeated skin contact may result in dryness.
Pictograms: No symbol required. Use caution to avoid excessive inhalation.
Precautionary Statements: Avoid breathing dust. Wash hands thoroughly after handling. Wear eye protection if splashing likely.
Chemical Name: Citric acid
CAS Number: 77-92-9
Concentration: Typical 1-5%
Chemical Name: Trisodium citrate dihydrate
CAS Number: 6132-04-3
Concentration: Typical 1-5%
Impurities: No known hazardous impurities present
Inhalation: Move to fresh air. If breathing is difficult, seek medical attention. Irritation should subside over time.
Skin Contact: Rinse skin with water. Remove contaminated clothing. Persistent irritation may call for medical advice.
Eye Contact: Rinse cautiously with water for several minutes. Remove contact lenses if present and easy to do. Seek attention for ongoing discomfort.
Ingestion: Rinse mouth. Drink plenty of water. Do not induce vomiting. Seek medical help if large quantities are consumed or if feeling unwell.
Extinguishing Media: Use water, foam, dry chemical, or carbon dioxide. Select extinguishing agent appropriate for surroundings.
Hazards from Combustion: Products may emit carbon oxides in a fire. Avoid breathing smoke.
Protective Equipment: Firefighters should wear self-contained breathing apparatus and standard turnout gear.
Explosion Data: Not considered to present an explosion hazard.
Spill Response: Avoid dust formation. Wear gloves and goggles to protect skin and eyes. Ventilate the area.
Cleaning Procedure: Sweep up spill using non-sparking tools and place in a labeled container for disposal. Wash residue from spill site with water to eliminate slipperiness.
Environmental Precautions: Prevent material from entering drains or sewers. Small quantities are not expected to pose significant environmental hazards.
Handling Precautions: Prevent inhalation of dust and contact with skin and eyes. Maintain good industrial hygiene. Avoid eating or drinking in work area. Shower and change clothes if necessary at end of shift.
Storage Conditions: Store tightly closed at room temperature away from strong oxidizers. Keep in a dry, well-ventilated location. Handle with care to prevent spills and accidents.
Incompatibilities: Strong oxidizing agents and strong bases. Citric acid may degrade slightly under humid conditions.
Engineering Measures: Use local exhaust ventilation to control dust generation. Provision for eyewash stations in the work area.
Personal Protective Equipment: Wear chemical-resistant gloves, safety goggles, and protective clothing suitable for laboratory settings. Respiratory protection advised for dusty operations.
Occupational Exposure Limits: Not established for citric acid or sodium citrate; minimize exposure as a precaution.
Form: Clear or slightly cloudy aqueous solution (or white crystalline powder in dehydrated mixes)
Odor: Odorless or faint acidic scent
pH: Typically ranges from 2.2 to 6.5 depending on ratio and concentration
Melting Point: Citric acid: 153°C, Sodium citrate: 300°C (decomposes)
Boiling Point: Not available for mixture, components are stable at room temperature in aqueous form
Solubility: Completely soluble in water
Vapor Pressure: Not significant at room temperature
Density: ~1.0-1.1 g/mL for dilute solutions
Flash Point: Not applicable (aqueous solution)
Other Data: No explosive or oxidizing properties noted
Chemical Stability: Stable under recommended storage and handling. Will not polymerize.
Reactivity: Citric acid can slowly react with basic substances and strong oxidizers. Sodium citrate stays inert under neutral conditions.
Hazardous Decomposition Products: Carbon monoxide, carbon dioxide under fire conditions.
Conditions to Avoid: Moisture exposure to dried material, high temperatures, incompatible substances.
Possible Routes of Exposure: Inhalation, skin contact, eye contact, ingestion
Symptoms: May cause mild skin irritation, eye redness or discomfort, and throat irritation if inhaled.
Acute Toxicity: Citric acid oral LD50 (rat): 3000-6000 mg/kg. Sodium citrate oral LD50 (rat): >8000 mg/kg. Low toxicity for brief exposures.
Chronic Toxicity: Not expected from normal laboratory use. Prolonged contact may de-fat skin.
Carcinogenicity: No component listed as carcinogen by NTP, IARC, or OSHA.
Aquatic Toxicity: Low toxicity expected for aquatic life at typical concentrations. Components rapidly biodegrade in standard wastewater treatment systems.
Persistence and Degradability: Citric acid and sodium citrate break down quickly by natural processes.
Bioaccumulation: Not likely due to high water solubility and metabolism in microorganisms.
Mobility in Soil: High mobility expected, material will leach through soil with water movement.
Waste Disposal: Dispose in accordance with local, regional, and national regulations. Triple-rinse containers before recycling or disposal.
Recommended Method: Dilute solution can be flushed to drain with copious water if allowed by local authority. Solid material should be placed in sealed container for authorized waste handler.
Precautions: Do not release into surface waters or sewers in concentrated form.
UN Number: Not regulated as hazardous for transport
Proper Shipping Name: Citric Acid Sodium Citrate Buffer solution
Transport Hazard Class: Not classified
Packing Group: None
Special Precautions: Protect containers from physical damage and moisture. Ship in well-sealed packaging to prevent leaks and spills.
TSCA: Listed
DSL/NDSL (Canada): Listed
REACH (EU): Components registered
SARA Title III Sections 302/313: Not regulated
California Proposition 65: Product does not contain chemicals subject to warning
Other Information: Not subject to additional national or international control under normal laboratory use
