Product Name: Citrulline Malate
Chemical Formula: C6H13N3O3·C4H6O5
SYNONYMS: 2-Amino-5-(carbamoylamino)pentanoic acid compound with malic acid
Relevant Uses: Dietary supplements, sports nutrition
Supplier Contact: Manufacturer or distributor information should be referenced according to labels
CAS Number: 54940-97-5
Emergency Phone: National Poison Center, local emergency contacts
Hazard Classification: Substance not classified as hazardous under GHS for most uses
Main Health Hazards: Can irritate eyes or skin on contact; inhalation of dust may cause mild respiratory discomfort
Physical Hazards: Low reactivity, non-flammable, non-explosive under ambient conditions
Environmental Hazards: Not classified as environmentally hazardous; avoid spillage and discharge into waterways
Signal Word: No signal word required
Hazard Statements: Prolonged exposure to powder can cause mechanical irritation to eyes, nose, or throat
Main Ingredient: L-Citrulline Malate
Chemical Nature: Mixture of nonprotein amino acid (Citrulline) and malic acid in a typical 2:1 molar ratio
Purity: Typically ≥ 99% pure
Impurities: Usually contains negligible levels of other amino acids, water, and trace elements below regulatory thresholds
Additives: May vary depending on manufacturer, often none included in pure powder
Other Ingredients: Not intentionally added; consult supplier for specifics
Eye Contact: Rinse immediately with plenty of water, remove contact lenses if worn, keep eyelids open, seek medical attention if irritation persists
Skin Contact: Wash with soap and water, remove any contaminated clothing, monitor for persistent irritation
Inhalation: Move to fresh air, seek medical help if irritation or respiratory symptoms develop
Ingestion: Rinse mouth with water, drink water to dilute, seek medical advice if feeling unwell
Most Important Symptoms: Itching, redness, coughing in sensitive individuals
Suitable Extinguishing Media: Water spray, carbon dioxide, dry chemical extinguisher, foam
Unsuitable Media: None reported
Special Hazards: Dust may form explosive mixtures with air at high concentrations; avoid heavy dust clouds near ignition sources
Protective Equipment: Full protective clothing, self-contained breathing apparatus for major fires
Decomposition Products: Carbon oxides, nitrogen oxides, small amounts of ammonia under intense heat
Personal Precautions: Wear dust mask, safety goggles, gloves to prevent contact
Environmental Precautions: Keep away from drains, surface, and groundwater systems
Cleanup Methods: Collect material by sweeping, shovel into labeled containers for proper disposal, avoid raising dust in the air
Spill Response: Ventilate area, wash spill site once material has been removed
Precautions for Safe Handling: Minimize dust generation, avoid contact with eyes and prolonged skin exposure
Hygiene Practices: Wash hands thoroughly after handling, do not eat or drink near work area
Storage Conditions: Store in sealed containers in a well-ventilated, dry area away from sunlight and moisture
Incompatible Materials: Avoid strong oxidizing agents, acids
Specific End Uses: See product label for details
Occupational Exposure Limits: Not established for Citrulline Malate
Engineering Controls: Use local exhaust ventilation in areas of high dust generation
Personal Protective Equipment (PPE): Safety glasses or goggles, protective gloves, disposable lab coat or apron, dust mask or respirator if powder concentrations are significant
Environmental Controls: Prevent large release into water sources
Special Requirements: Emergency eyewash stations in work area
Appearance: White to off-white crystalline or powder
Odor: Odorless or slight acid scent
pH: 2.5 – 3.0 (1% solution in water)
Melting Point: Decomposes before melting
Solubility: Freely soluble in water, slightly soluble in ethanol
Density: Approximately 1.6 g/cm³
Particle Size: Fine powder, varies by manufacturer
Boiling Point: Not applicable
Vapor Pressure: Not applicable
Flash Point: Not flammable
Chemical Stability: Stable under recommended storage conditions
Reactivity: Low under normal circumstances
Conditions to Avoid: Excess humidity, strong heat sources, direct sunlight
Incompatible Materials: Strong oxidizing agents, strong acids
Hazardous Decomposition Products: Nitrogen oxides, carbon oxides under combustion
Likely Routes of Exposure: Inhalation, skin contact, ingestion, eye contact
Acute Toxicity: Oral LD50 not established in humans; low toxicity reported in animal studies
Chronic Effects: No evidence of chronic toxicity or carcinogenicity in available studies
Sensitization: Not known to cause allergic reactions
Symptoms of Overexposure: Mild irritation to eyes, skin, or respiratory tract in sensitive individuals
Medical Conditions Aggravated: Pre-existing eye or respiratory conditions
Ecotoxicity: No evidence of toxicity to aquatic organisms at expected concentrations
Persistence and Degradability: Biodegradable, degrades to nitrogen, carbon, and water under environmental conditions
Bioaccumulation Potential: Low; not expected to bioaccumulate
Mobility in Soil: Dissolves in water, mobile in aqueous environments
Other Effects: Discharge into large bodies of water may contribute to nutrient load; avoid unnecessary spillage
Product Waste: Dispose of according to local, regional, and national regulations; consider landfilling or incineration at approved facilities if appropriate
Waste Packaging: Rinse well before recycling, incinerate or landfill in approved manner
Special Precautions: Prevent contamination of groundwater or soil; do not dispose directly to sewers
UN Number: Not regulated under ADR, IMDG, IATA, DOT
Proper Shipping Name: Not applicable
Transport Hazard Class: Not hazardous for transport
Packing Group: Not assigned
Marine Pollutant: Not a marine pollutant
Special Transport Precautions: Keep containers tightly closed and dry during transport
International Regulations: Not listed as hazardous substance under major international regulations
OSHA Status: Not specifically regulated as hazardous by OSHA
TSCA Inventory: Listed
REACH Status: Not subject to registration under current requirements
Other Regulations: Follow applicable state, national, and regional requirements for product safety, labeling, and worker protection; not listed on schedules for controlled or heavily restricted substances
