Product Name: Diethyl Malate
Chemical Name: Diethyl 2-hydroxybutanedioate
Synonyms: Malic acid diethyl ester
CAS Number: 87-13-8
Molecular Formula: C8H14O5
Molecular Weight: 190.19 g/mol
Manufacturer: Available from specialty chemical suppliers
Recommended Use: Intermediate in organic synthesis, used in flavors and fragrances
Contact Information: Refer to supplier’s documentation for specific details
Classification: Eye irritant, mild skin irritant
Label Elements: Warning symbol, signal word “Caution”
Hazard Statements: May cause mild irritation to eyes and skin upon contact; ingestion may cause digestive discomfort
Precautionary Statements: Use proper ventilation, wear suitable protective gear, avoid contact with eyes and skin
Physical Hazards: Flammable liquid and vapor
Environmental Hazards: Can contribute to waterway contamination with high spillage
Chemical Identity: Diethyl Malate
Chemical Formula: C8H14O5
Concentration: Typically 98% or higher by weight
Impurities: Less than 2% water or minor esters possible depending on grade and supplier
Eye Contact: Rinse cautiously with water for several minutes, remove contact lenses if present and easy to remove
Skin Contact: Wash thoroughly with soap and water
Inhalation: Move to fresh air, keep at rest
Ingestion: Rinse mouth, seek medical advice if discomfort persists
General Advice: Seek medical attention if symptoms continue after basic first aid
Suitable Extinguishing Media: Use dry chemical, alcohol-resistant foam, CO2, or water spray
Special Hazards: Flammable vapors can form explosive mixtures with air; combustion may produce carbon oxides
Protective Equipment: Wear self-contained breathing apparatus and full protective gear
Special Procedures: Cool containers with water jet to prevent pressure build-up or explosion
Personal Precautions: Use personal protective equipment, avoid contact with eyes and skin, ensure proper ventilation
Environmental Precautions: Prevent entry into drains, surface water, or soil; inform authorities if significant spill occurs
Methods for Cleanup: Use inert absorbent material, collect in suitable container, clean area with water, dispose according to regulations
Containment: Evacuate non-essential personnel and control source of leak if safe
Handling: Use only in well-ventilated areas, avoid inhaling vapors, prevent contact with skin and eyes, wear appropriate PPE
Storage: Store in tightly closed, clearly labeled containers in a cool, dry, well-ventilated place away from heat sources and incompatible materials
Special Advice: Keep away from open flames, hot surfaces, and sources of ignition; ground containers when transferring liquid
Exposure Limits: No established occupational exposure limit values
Engineering Controls: Local exhaust ventilation recommended
Respiratory Protection: Use NIOSH-approved respirator if vapors reach significant concentration
Hand Protection: Chemical-resistant gloves
Eye Protection: Safety glasses with side shields
Skin Protection: Protective clothing to reduce exposure
Appearance: Colorless to pale yellow liquid
Odor: Mild ester odor, fruity
pH: Not applicable (esters do not ionize in water)
Boiling Point: About 210°C (410°F)
Melting Point: -24°C (-11°F)
Flash Point: About 87°C (189°F)
Density: 1.08 g/cm³ at 20°C
Solubility: Slightly soluble in water, miscible with alcohols, ethers
Vapor Pressure: 0.06 mmHg at 25°C
Partition Coefficient (log Kow): 1.15
Chemical Stability: Stable under recommended storage conditions
Reactivity: No dangerous reaction known with regular use
Conditions to Avoid: Heat, open flames, strong oxidizers
Incompatible Materials: Strong acids, bases, and oxidizing agents
Hazardous Decomposition Products: Burning produces carbon monoxide, carbon dioxide, and potentially irritating volatiles
Acute Toxicity: Oral LD50 (rat): >2000 mg/kg
Skin Irritation: May cause mild irritation upon prolonged or repeated exposure
Eye Contact: Possible irritation, redness, or discomfort
Inhalation: No data on direct inhalation toxicity, vapors may irritate respiratory tract
Chronic Effects: No expected symptoms with typical industrial use, long-term data limited
Carcinogenicity: Not listed as carcinogenic by IARC, NTP, or OSHA
Mutagenicity: No evidence in literature
Sensitization: Not expected to cause sensitization with proper handling
Ecotoxicity: Not classified as hazardous to aquatic life
Persistence and Degradability: Expected to be readily biodegradable in water and soil by microbial action
Bioaccumulation Potential: Low, due to moderate water solubility and log Kow
Mobility in Soil: Compound expected to move through soil due to solubility but likely degraded
Other Adverse Effects: Avoid significant discharge into environment to prevent localized impact
Waste Disposal Method: Treat as organic chemical waste, incinerate in equipped facility or dispose according to local, state, and national regulations
Contaminated Packaging: Rinse and recycle container if possible, else dispose as hazardous waste
Special Precautions: Do not discharge to drains or environment without proper authorization
UN Number: UN3272
Proper Shipping Name: Esters, n.o.s. (contains Diethyl Malate)
Transport Hazard Class: 3 (Flammable liquids)
Packing Group: III (minor hazard)
Environmental Hazards: Not a marine pollutant
Additional Info: Use approved containers and labeling, comply with all modal-specific regulations (ADR, IMDG, IATA)
US TSCA: Listed
EU REACH: Not registered in the Annex SVHC
Canada DSL/NDSL: Listed
Australia AICS: Listed
WHMIS Classification: Not controlled
OSHA: Non-regulated chemical under typical handling
Labeling Requirements: Comply with GHS-based regulations, signal word “Warning”, hazard pictograms for irritant and flammable
