Material Safety Data Sheet - Enclomiphene Citrate

Identification

Product Name: Enclomiphene Citrate
Synonyms: (E)-2-(4-(2-chloro-1,2-diphenylethenyl)phenoxy)triethylamine citrate
Chemical Family: Triphenylethylene derivative
CAS Number: 7599-79-3
Manufacturer: Noted pharmaceutical suppliers
Emergency Contact: Refer to local guidelines and poison control
Recommended Use: Research and medical settings only
Restrictions on Use: Non-approved for general consumer use; restricted to professional handling

Hazard Identification

GHS Classification: Eye irritation, Skin irritation, Reproductive toxicity
Hazard Statements: Causes moderate eye and skin irritation, may damage fertility, risk of harm if swallowed or inhaled
Pictograms: Exclamation mark, Health hazard
Signal Word: Warning
Precautionary Statements: Avoid breathing dust, wash exposed skin, keep away from food and drink, wear protective equipment
Other Hazards: Pharmaceutical active compound, may enter environment if improperly handled

Composition / Information on Ingredients

Chemical: Enclomiphene Citrate
Purity: Typical range 98%+
Molecular Formula: C32H36ClNO8
Relevant Impurities: Trace levels of related triphenylethylene derivatives

First Aid Measures

Inhalation: Move affected person to fresh air; seek medical advice as needed
Skin Contact: Remove contaminated clothing; wash skin with soap and water
Eye Contact: Rinse immediately with plenty of water; seek medical help if irritation persists
Ingestion: Rinse mouth thoroughly; do not induce vomiting; consult a physician immediately
Most Important Symptoms: Irritation, possible endocrine effects, stomach discomfort
Advice to Doctor: Treat symptomatically; monitor reproductive hormone changes

Fire-Fighting Measures

Suitable Extinguishing Media: Dry chemical, CO2, foam, water spray
Unsuitable Media: Direct water jet may spread powder
Hazardous Combustion Products: Carbon dioxide, carbon monoxide, hydrogen chloride, nitrogen oxides
Protective Equipment: Wear self-contained breathing apparatus, full protective gear
Special Procedures: Contain runoff to minimize environmental contamination

Accidental Release Measures

Personal Precautions: Use respiratory protection, gloves, chemical goggles
Environmental Precautions: Prevent entry to drains or waterways, inform responsible authorities
Methods for Cleanup: Carefully collect spilled material using non-sparking tools, place into waste containers, ventilate area
Additional Advice: Avoid raising dust, decontaminate area using suitable detergents

Handling and Storage

Handling: Avoid contact with eyes and skin, handle under fume hood if dust present, never pipette by mouth
Storage: Keep sealed and dry, store at room temperature in original container, keep away from sunlight and incompatible materials
Incompatible Materials: Strong oxidizers, acids, alkalis
Hygiene Storage: Wash hands after handling, do not eat, drink, or smoke near chemical

Exposure Controls and Personal Protection

Engineering Controls: Local exhaust ventilation, laboratory fume hood
Personal Protective Equipment: Laboratory gloves (nitrile preferred), chemical safety goggles, laboratory coat
Respiratory Protection: Dust respirator or mask if powder airborne
Exposure Limits: No established national occupational exposure limits; minimize exposure as for active pharmaceuticals
Environmental Exposure: Prevent environmental release, use closed systems where possible

Physical and Chemical Properties

Appearance: White to off-white crystalline powder
Odor: Odorless
Boiling Point: Not available
Melting Point: About 178–185°C
Solubility: Freely soluble in methanol, soluble in ethanol, slightly soluble in water
pH: Not determined
Vapor Pressure: Not available
Molecular Weight: Approximately 598.1 g/mol
Other Data: Stable under normal laboratory conditions, dust may form explosive mixtures with air

Stability and Reactivity

Chemical Stability: Stable under recommended storage and handling conditions
Conditions to Avoid: Heat, direct sunlight, moisture, incompatible substances
Incompatible Materials: Strong acids, bases, oxidizing agents
Hazardous Decomposition Products: Fumes including carbon oxides, hydrochloric acid, nitrogen compounds
Polymerization: No hazardous polymerization reported

Toxicological Information

Likely Routes of Exposure: Skin, eyes, ingestion, inhalation
Acute Toxicity: Mild to moderate irritation; larger doses may affect hormone systems
Chronic Toxicity: Long-term exposure may impact reproductive health; no sufficient human data
Symptoms: Drowsiness, dermatitis, reproductive system effects
Carcinogenicity: Not classified by IARC
Mutagenicity: No indication from animal studies
Reproductive Toxicity: Documented effects on reproductive organs and fertility in laboratory animals

Ecological Information

Aquatic Toxicity: May be harmful to aquatic organisms at high concentrations
Persistence and Degradability: Compound may not degrade rapidly; could persist in environment
Bioaccumulative Potential: Moderate; potential for bioconcentration in aquatic life
Mobility in Soil: Unknown; likely to bind to sediments
Other Adverse Effects: Pharmaceutical compound—potential risk for wildlife exposed to waste streams

Disposal Considerations

Disposal Methods: Use chemical waste incineration in controlled environment, consult local, state, national regulations
Contaminated Packaging: Triple rinse and dispose according to official guidelines
Special Precautions: Label all waste for proper hazard identification
Avoid: Flushing into sewer systems, direct release to surface waters

Transport Information

UN Number: Not regulated for transport
Proper Shipping Name: Laboratory chemical, not otherwise specified
Transport Hazard Class: Not applicable unless packed with other hazardous substances
Packing Group: Not specified
Special Precautions for Transport: Ship in secure, clearly labeled containers with tamper evidence
Environmental Hazards: Not a marine pollutant

Regulatory Information

Inventory Listings: May appear on local regulated chemical inventories
OSHA Status: Not classified as hazardous chemical under US OSHA regulations
SARA Section 313: Not subject to reporting
TSCA Status: Research use only; not for commercial or consumer use
EU Regulation: Notified under REACH for specific uses; restricted to trained professionals
Other Regulations: Handle as a substance with the potential for significant biological activity; follow institutional safety protocols