Material Safety Data Sheet: Ethacridine Lactate Monohydrate

Identification

Product Name: Ethacridine Lactate Monohydrate
Chemical Formula: C18H21N3O4·C3H6O3·H2O
Synonyms: Rivanol, Acrinol
CAS Number: 6402-23-9
Manufacturer: [Insert manufacturer contact information]
Recommended Use: Topical antiseptic, research chemical
Restrictions on Use: Not for human consumption or medical injection
Emergency Contact: [Manufacturer or supplier telephone and address]

Hazard Identification

Hazard Classification: Eye irritation (Category 2A), Skin irritation (Category 2), Acute toxicity oral (Category 4)
Signal Word: Warning
Hazard Statements: Causes skin and eye irritation, may be harmful if ingested, may cause respiratory discomfort.
Pictograms: Exclamation mark
Precautionary Statements: Avoid contact with eyes and skin. Wear protective gear. Use only in a well-ventilated area.
Potential Health Effects: Irritation of skin, eyes, and mucosa; ingestion may cause nausea, vomiting, or gastrointestinal irritation.
Environmental Hazards: Harmful to aquatic life with long lasting effects. Avoid release into the environment.

Composition / Information on Ingredients

Chemical Name: Ethacridine Lactate Monohydrate
Common Name: Ethacridine
Concentration: ≥98%
Impurities: Trace organic solvents (<0.1%)
Additives: None
Molecular Weight: 423.45 g/mol

First Aid Measures

Skin Contact: Wash with soap and plenty of water. Remove contaminated clothing. If irritation persists, seek medical attention.
Eye Contact: Rinse cautiously with water for several minutes. Remove contact lenses. Continue rinsing. Get medical attention if symptoms develop.
Inhalation: Move to fresh air promptly. Monitor for difficulty breathing. Seek medical advice if symptoms do not resolve.
Ingestion: Rinse mouth. Do not induce vomiting. Drink water if conscious. Seek immediate medical help.
Most Important Symptoms: Redness, irritation, burning sensation.
Note to Physician: Symptomatic and supportive treatment recommended.

Fire-Fighting Measures

Suitable Extinguishing Media: Water spray, dry chemical, carbon dioxide, or foam.
Unsuitable Extinguishing Media: None known.
Specific Hazards: May emit toxic fumes of nitrogen oxides, carbon oxides upon combustion.
Special Equipment for Firefighters: Full protective suit, self-contained breathing apparatus.
Firefighting Advice: Avoid inhaling fumes. Cool fire-exposed containers with water.
Explosion Data: No explosion hazard expected with normal handling.

Accidental Release Measures

Personal Precautions: Wear protective clothing, gloves, goggles, and respiratory protection.
Environmental Precautions: Prevent entry to drains, sewers, and waterways. Report significant releases to authorities.
Methods for Clean Up: Sweep up and place in a suitable container for disposal. Wash area with water and detergent to remove residues.
Other Advice: Ventilate affected area. Avoid dust formation.

Handling and Storage

Precautions for Safe Handling: Avoid contact with skin, eyes, and clothing. Minimize dust generation and accumulation.
Safe Storage Conditions: Store in tightly closed containers, in a cool, dry, well-ventilated place.
Storage Incompatibilities: Acids, alkalis, strong oxidizing agents.
Hygiene Practices: Wash hands thoroughly after handling. Do not eat, drink, or smoke in work area.
Special Packaging Requirements: Use containers resistant to chemical attack, properly labeled and secure.

Exposure Controls and Personal Protection

Exposure Limits: No occupational exposure limits established.
Engineering Controls: Local exhaust ventilation, eyewash stations, and safety showers required.
Personal Protective Equipment: Chemical splash goggles, gloves, lab coat or apron, and appropriate respirator if dusts are generated.
Respiratory Protection: Use a NIOSH/MSHA-approved respirator for dust when needed.
Environmental Controls: Minimize release to the environment.

Physical and Chemical Properties

Appearance: Yellow crystalline powder
Odor: Odorless or faint medicinal smell
pH (1% solution): 3.5–5.5
Melting Point: 220–225°C (decomposes)
Boiling Point: Not applicable (decomposes)
Solubility: Soluble in water, slightly soluble in alcohol
Vapor Pressure: Not available
Density: Approximately 1.4 g/cm³
Partition Coefficient (log Pow): Not determined
Other Properties: Stable under normal storage, non-flammable solid

Stability and Reactivity

Chemical Stability: Stable under standard conditions.
Conditions to Avoid: Strong heating, incompatible substances, direct sunlight.
Incompatible Materials: Strong acids, bases, oxidizers.
Hazardous Decomposition: Nitrogen oxides, carbon monoxide, carbon dioxide on decomposition.
Polymerization: Will not occur under normal conditions.

Toxicological Information

Acute Toxicity: LD50 (oral, rat): >2000 mg/kg
Skin Irritation: Causes irritation on prolonged contact.
Eye Irritation: Causes severe irritation.
Respiratory Effects: Dust inhalation may cause coughing, discomfort.
Chronic Exposure: No evidence of carcinogenicity or reproductive toxicity.
Sensitization: Not expected to sensitize skin.
Other Information: Prolonged exposure not recommended.

Ecological Information

Ecotoxicity: Harmful to aquatic organisms.
Persistence and Degradability: Not readily biodegradable.
Bioaccumulative Potential: No significant bioaccumulation expected.
Mobility in Soil: Expected to be immobile or low mobility.
Other Adverse Effects: Avoid environmental release; notify authorities if large spills occur.

Disposal Considerations

Disposal Methods: Dispose of product and contaminated packaging in accordance with local, state, and federal regulations.
Incineration: Chemical incinerator equipped with afterburner and scrubber recommended.
Contaminated Containers: Rinse thoroughly, then destroy or recycle according to regulations.
Waste Codes: Not listed as hazardous waste.

Transport Information

UN Number: Not regulated for transport.
Proper Shipping Name: Not classified as dangerous goods.
Transport Hazard Class: Not applicable.
Packing Group: Not assigned.
Environmental Hazards: Not classified as a marine pollutant.
Special Precautions: Protect from extreme temperatures. Prevent spillage during transport.

Regulatory Information

OSHA Status: Not regulated.
TSCA Status: Listed.
DSL/NDSL Status: Included.
EU Regulation: Not hazardous according to Regulation (EC) No 1272/2008.
SARA Title III Sections 302/304/311/312/313: Not listed.
WHMIS Classification: Not controlled.
Other Local or National Regulations: Ensure compliance with applicable governmental regulations.