Product Name: Lactate Dehydrogenase
Synonyms: LDH, Lactic Acid Dehydrogenase
CAS Number: 9001-60-9
Uses: Clinical diagnostics, biochemical research, enzymatic reactions
Manufacturer: Data available from supplier
Emergency Contact: Refer to company emergency line
Recommended Use Restrictions: Laboratory and research use only
Classification: Not classified as hazardous under GHS for most preparations; may still cause allergic reaction or irritation in sensitive individuals
Hazard Statements: May cause respiratory or skin sensitization, mild eye irritation, possible irritation to mucosal surfaces
Signal Word: Caution
Symbol(s): Health hazard for allergic potential
Precautionary Statements: Avoid inhalation and contact with skin or eyes; do not ingest
Potential Health Effects: Dust or aerosols can irritate respiratory tract, contact may cause skin rash, redness or itching
Chronic Effects: Prolonged or repeated exposure could induce sensitization or allergic reaction in some individuals
Chemical Name: Lactate Dehydrogenase
Chemical Formula: Protein, C27H36N6O10 for the catalytic subunit
Concentration: ≥95% by SDS-PAGE
Component: Purified enzyme, trace buffer salts or stabilizers
Impurities: No significant non-protein hazards known
Additives: May include sodium chloride, phosphate, stabilizing proteins (e.g., BSA), or lyophilized powder excipients
Inhalation: Move person to fresh air, monitor breathing, administer oxygen if breathing becomes difficult, seek medical attention for any persistent symptoms
Skin Contact: Wash area thoroughly with soap and water, remove contaminated clothing, monitor for irritation or allergic reactions, consult a physician if symptoms persist
Eye Contact: Rinse immediately with plenty of water for at least 15 minutes, lift eyelids occasionally, seek medical advice for continued discomfort
Ingestion: Rinse mouth with water (do not induce vomiting), give water if conscious, call a physician or poison center
Most important symptoms/effects: Allergic reaction, itching, rash, difficulty breathing
Advice to Physician: Treat based on symptoms, pay attention to allergic or respiratory complications
Extinguishing Media: Use water spray, alcohol-resistant foam, dry chemical, or carbon dioxide
Specific Hazards: Fine powders could form explosive mixtures with air, toxic fumes possible during decomposition (CO₂, NOₓ)
Protective Equipment: Wear full protective gear including self-contained breathing apparatus
Special Procedures: Remove containers from fire area if safe; use water spray to cool exposed containers; prevent fire-fighting runoff from entering waterways
Personal Precautions: Wear gloves, protective clothing, safety goggles, and an approved NIOSH respirator in case of dust
Environmental Precautions: Prevent material from entering drains or water courses, contain spill with absorbent materials, report large spills to authorities
Cleanup Methods: Sweep up without creating dust, collect in appropriate containers, ventilate area, clean surfaces with damp cloth, dispose according to regulations
Decontamination: Scrub potentially contaminated surfaces with soapy water, avoid direct contact
Safe Handling: Work in well-ventilated area, avoid raising dust, avoid inhalation or direct contact with skin and eyes, wash hands after use, use dedicated containers
Storage Conditions: Store at -20°C to -80°C (as specified on label); protect from light, excessive moisture, and temperature fluctuation; keep sealed containers
Incompatible Materials: Oxidizers, strong acids or bases may degrade protein; do not store with food or drink
Special Requirements: Label all storage units, restrict access to trained personnel
Occupational Exposure Limits: No specific OSHA or ACGIH limits; minimize exposure (nuisance dust limits may apply)
Engineering Controls: Use biosafety cabinet, fume hood, or local exhaust during handling
Personal Protective Equipment: Gloves (nitrile or latex), protective lab coat, safety goggles, particulate respirator for powders or aerosols
Hygiene: Wash hands, arms, and face thoroughly after handling; do not eat, drink, or smoke in work area
Environmental Controls: Methods for safe disposal of runoff and waste
Appearance: White to off-white lyophilized powder, sometimes clear solution
Odor: Odorless
pH: Neutral near 7.0 (aqueous solution)
Melting Point/Freezing Point: Not applicable (protein denatures instead of melting)
Solubility: Freely soluble in water, insoluble in most organic solvents
Boiling Point: Not applicable
Flash Point: Not determined
Decomposition Temperature: Above 60°C
Molecular Weight: Approx. 140 kDa (tetrameric form)
Vapor Pressure: Not applicable
Density: Not measured, powder is light and fluffy
Other Data: Stable as lyophilized powder under -20°C; active enzyme loses function at room temperature over time
Chemical Stability: Stable under recommended storage, loses activity rapidly under heat or moisture
Reactivity: No hazardous reactions under normal conditions
Possibility of Hazardous Reactions: No polymerization; avoid strong oxidizing/reducing agents
Conditions to Avoid: High temperature, moisture, strong acids/bases
Incompatible Materials: Oxidizing agents, strong acids, solvents that denature proteins (e.g., acetone)
Hazardous Decomposition Products: Nitrogen oxides, carbon monoxide or dioxide if incinerated
Acute Toxicity: No known issues at low concentrations used for laboratory work; not expected to be acutely toxic
Routes of Exposure: Inhalation, skin/eye contact, ingestion
Symptoms: Respiratory or dermal sensitization, mild irritation possible
Chronic Toxicity: Sensitization with repeated exposure
Carcinogenicity: No evidence of carcinogenic or mutagenic effects
Reproductive Toxicity: Not reported
Other Effects: Not classified as hazardous for reproductive or developmental endpoints
Ecotoxicity: Expected to be low; protein is readily biodegradable, does not bioaccumulate
Persistence and Degradability: Decomposes rapidly in the environment
Bioaccumulation: Not considered to accumulate in organisms
Mobility: Will disperse in water, broken down by microorganisms
Other Effects: Avoid heavy quantities entering waterways as high biological oxygen demand (BOD) may affect microbial activity
Waste Disposal Methods: Dispose as biological waste according to institutional guidelines; autoclave or incinerate for destruction
Contaminated Packaging: Treat as chemical waste; rinse and discard through regular program
Disposal Precautions: Avoid disposal into drains or natural water courses; follow all local, regional, and national regulations
Special Considerations: Keep waste labeled to prevent accidental exposure
UN Number: Not regulated for transport as dangerous goods
UN Proper Shipping Name: Not applicable
Transport Hazard Class: Non-hazardous under typical shipping conditions
Packing Group: Not designated
Environmental Hazards: None known; standard biological sample precautions apply
Special Precautions: Ship with cold packs/dry ice preferably for active enzyme; avoid rough handling
Labels: Standard “Biological Substance, Category B” as a precaution
US Regulations: Not listed by OSHA, TSCA, SARA, or CERCLA as hazardous; standard lab chemical rules apply
EU Regulations: Not classified as hazardous under CLP, not subject to REACH restrictions
Other International Transport: May require IATA or DOT guidelines for biological materials
Labeling and Classification: Not classified as toxic or carcinogenic; treat as low-hazard laboratory reagent
Worker Protection: Provide access to Safety Data Sheet, train staff on safe enzyme handling practices
Inventory Status: Exempt from chemical inventory requirements under most academic and research conditions
