Product Name: Lactate Oxidase
Synonyms: LOX, EC 1.13.12.4
Recommended Use: Diagnostic reagent, research applications
Supplier: [Company Details]
Address: [Supplier Address]
Emergency Contact: [Supplier Emergency Number]
CAS Number: 9028-85-7
UN Number: Not classified
GHS Label: Not classified under GHS
Classification: Not hazardous under normal conditions per GHS criteria
Label Elements: No pictogram, no signal word
Hazard Statement: No significant hazards known; avoid ingestion, inhalation, or skin and eye contact
Precautionary Statements: Handle following laboratory safety protocols; use appropriate protective equipment
Other Hazards: Dust may cause mild irritation to respiratory tract; repeated contact may cause slight skin irritation in sensitive individuals
Chemical Name: Lactate Oxidase
Purity: ≥90% (may vary by manufacturer)
EC Number: 232-864-8
Enzyme Source: Bacterial fermentation (e.g., Aerococcus viridans)
Formulation: Often mixed with stabilizers such as buffer salts or sucrose; presence of minor impurities possible depending on manufacturing process
Inhalation: Remove person to fresh air, seek medical attention if symptoms develop
Skin Contact: Wash thoroughly with soap and water, remove contaminated clothing
Eye Contact: Rinse gently with water for at least 15 minutes, seek medical help if irritation persists
Ingestion: Rinse mouth with water, do not induce vomiting, consult healthcare professional
Main Symptoms: Irritation to skin, eyes, or respiratory tract
Notes to Physician: Treat symptomatically, monitor for allergic reactions in sensitized individuals
Suitable Extinguishing Media: Water spray, foam, dry chemical, or CO2
Specific Hazards: No special hazards for small quantities; combustion may produce carbon oxides, nitrogen oxides
Protective Equipment: Firefighters should wear self-contained breathing apparatus and protective clothing
Special Procedures: Use water spray to cool containers near fire; avoid inhaling combustion fumes
Explosion Risk: Fine particulate may form explosive air-dust mixtures under rare circumstances, avoid creating dust clouds
Personal Precautions: Wear gloves, safety goggles, lab coat; avoid creating and inhaling dust
Environmental Precautions: Prevent from entering drains or waterways; contain spill immediately
Methods for Cleanup: Scoop up or vacuum without raising dust; place material in a suitable, labeled disposal container
Decontamination: Clean area with water and detergents, ventilate room
Reporting: Report significant spills as per local regulations; minor spills typically do not require special notification
Handling: Keep in a well-ventilated area; avoid contact with skin, eyes and mucous membranes; wear lab-appropriate PPE; wash hands after use
Storage Conditions: Store tightly closed at 2–8°C (refrigerated) away from direct sunlight; keep container dry and upright
Incompatibilities: Strong oxidizers, acids, and bases may inactivate enzyme; store separate from food
Special Precautions: Minimize exposure to air and moisture to maintain enzymatic activity; label containers clearly
Exposure Limits: None established for lactate oxidase by OSHA, ACGIH, or NIOSH
Engineering Controls: Use in fume hood or well-ventilated area for large-scale operations; employ local exhaust if dust generation likely
Personal Protection: Wear safety goggles, laboratory gloves, protective clothing; for large-scale, consider N95 dust mask
Hygiene Measures: Do not eat, drink, or smoke while handling; wash hands before breaks and after finishing work
Environmental Controls: Prevent spills from reaching sewer systems or open water
Appearance: White to off-white powder or lyophilized solid
Odor: Odorless or mild protein-like
pH (in solution): Typically near neutral (6–8)
Melting Point: Not determined, decomposes before melting
Solubility: Soluble in water, forms clear to slightly opalescent solution
Boiling Point: Not applicable
Flash Point: Not applicable
Vapor Pressure: Not applicable (nonvolatile)
Density: 1.2–1.3 g/cm3
Stability: Stable under recommended storage conditions
Decomposition: Thermal decomposition may yield CO2, NOx
Reactivity: Stable at ambient temperature and pressure
Chemical Stability: Maintains activity if kept cool and dry; loss of function when exposed to heat, acid, alkali, or strong oxidants
Hazardous Reactions: None expected under normal uses
Incompatible Materials: Avoid strong acids, bases, oxidizers; avoid moisture which can cause clumping
Decomposition Products: Burning or prolonged exposure to high temperature generates oxides of carbon or nitrogen, possibly toxic in confined area
Acute Toxicity: Not known to be toxic by oral, inhalation, or dermal routes in small lab-scale exposures
Chronic Effects: No chronic health effects reported in literature for normal laboratory use; no evidence of carcinogenicity or reproductive toxicity
Irritation: May cause mechanical irritation to skin, eyes, respiratory tract
Sensitization: Rare cases of allergic reactions possible; those with protein allergies should avoid unnecessary exposure
Symptoms of Overexposure: Redness, itching, coughing, sneezing
Further Data: No significant animal or human toxicity data available for lactate oxidase; safe handling practices minimize risks
Ecotoxicity: Not expected to harm aquatic or terrestrial life significantly; broken down by natural biological processes
Persistence and Degradability: Enzyme biodegrades rapidly in natural environment; short environmental half-life
Bioaccumulation: No potential for bioaccumulation due to proteinaceous nature
Mobility: Soluble in water, could move with surface runoff from large spills
Aquatic Toxicity: Release large amounts may cause local oxygen depletion during decomposition
Waste Treatment Methods: Small amounts suitable for general laboratory trash when deactivated by autoclaving or suitable disinfectant
Disposal of Product: Use local regulations for nonhazardous organic waste; do not release into sewer beyond trace quantities
Disposal of Packaging: Clean containers thoroughly before recycling or disposal; comply with reuse and recycling guidelines
Precautions: Avoid disposal with incompatible materials; ensure enzyme is not accessible for unauthorized or unintended use
UN Number: Not regulated for transport
Transport Hazard Class: Not applicable
Packing Group: Not applicable
Shipping Name: Not restricted; ship as non-hazardous, temperature-controlled if required for stability
Special Precautions: Use original container; keep dry and cool during transport, secure to avoid spillage or damage
Regulatory Status: Not classified as dangerous goods under IATA, IMDG, or DOT rules
TSCA: Lactate oxidase not listed, considered research chemical
REACH: Not registered, used in research and diagnostic settings
SARA Title III: Not subject to reporting requirements
California Prop 65: Contains no chemicals known to cause cancer or reproductive harm
GHS Classification: Not regulated
Workplace Safety: Comply with local, regional, national safety regulations for laboratory use of non-hazardous enzymes
Labelling: Proper identification and hazard communication must follow OSHA HazCom or local equivalent
