Product Name: Malate Dehydrogenase
Synonyms: MDH, L-Malate:NAD+ oxidoreductase
Chemical Formula: Protein, varies by source
Recommended Use: Laboratory reagent, research and biochemical analysis
Supplier: Refer to manufacturer for specific details
CAS Number: 9001-62-1
Emergency Phone: Refer to supplier’s specific number
Contact Email: Provided by supplier or local representative
GHS Classification: Not classified as hazardous according to available data
Hazard Statements: May cause slight irritation to eyes, skin, and respiratory tract if handled improperly
Signal Word: None
Pictograms: None
Precautionary Measures: Minimize dust formation, use adequate ventilation to prevent large inhalation exposure, practice good hygiene
Main Ingredient: Malate Dehydrogenase enzyme protein, concentration varies
Other Components: Buffer salts such as potassium phosphate, sodium chloride, stabilizers like glycerol
Impurities: Potential presence of trace microbial or process-origin substances, with details provided in batch-specific Certificate of Analysis
Purity: Typically >90% pure enzyme, varies by product source
Eye Contact: Rinse cautiously with water, remove contact lenses if present, continue rinsing, seek medical attention if irritation persists
Skin Contact: Wash with soap and water, remove contaminated clothing, seek medical advice for persistent irritation
Inhalation: Move to fresh air, seek medical attention if discomfort develops
Ingestion: Rinse mouth with water, do not induce vomiting, seek medical advice if feeling unwell
Advice to Physicians: Individual symptoms may vary, treat supportively based on clinical presentation
Suitable Extinguishing Media: Use water spray, dry chemical, foam, or carbon dioxide depending on surrounding fire
Specific Hazards: Proteinaceous material may decompose to emit carbon and nitrogen oxides in event of fire
Protective Equipment for Firefighters: Wear self-contained breathing apparatus and protective clothing
Special Precautions: Avoid inhaling fumes, move containers from fire area if safe to do so
Personal Precautions: Use standard protective equipment including gloves and lab coat, avoid generating dust
Environmental Precautions: Prevent further leakage or spillage if safe without raising dust, avoid discharge to drains
Cleanup Methods: Sweep up gently, place in properly labelled container for disposal, ventilate area, clean surface with appropriate disinfectant
Handling: Handle enzyme solutions or powders in a laboratory fume hood where possible, minimize dust generation, avoid contact with eyes, skin, and clothing, wash hands thoroughly after handling
Storage: Keep container tightly closed in a dry, cold (recommended 2–8°C) environment, avoid exposure to sunlight and incompatible materials such as strong acids or bases, specific storage temperature may depend on supplier instructions
Engineering Controls: Work in well-ventilated areas, use local exhaust ventilation or fume hood if dust or aerosols occur
Personal Protective Equipment: Wear laboratory gloves (nitrile or latex), safety goggles or glasses, lab coat
Respiratory Protection: Not required under normal laboratory use, use particulate respirator if large quantities or dust are generated
Hygiene Measures: Wash hands after manual handling, avoid eating, drinking, or smoking during use
Appearance: White to off-white powder or liquid suspension
Odor: Odorless
Odor Threshold: Not determined
pH: Solution typically neutral (pH 6.5–8.0)
Melting Point/Freezing Point: Not applicable (protein)
Boiling Point: Not applicable
Flash Point: Not applicable
Relative Density: Not determined
Solubility: Soluble in water, insoluble in organic solvents
Vapor Pressure: Not applicable
Partition Coefficient: Not applicable
Decomposition Temperature: Protein denatures above 40°C
Chemical Stability: Stable under suggested storage conditions, degraded by high temperatures and sunlight exposure
Incompatible Materials: Strong acids, strong bases, oxidizing agents
Hazardous Decomposition Products: Carbon oxides and nitrogen oxides may form upon burning
Polymerization: Will not occur
Reactivity: No known dangerous reactions under normal laboratory conditions
Likely Routes of Exposure: Inhalation, ingestion, skin and eye contact
Potential Health Effects: May irritate eyes and skin, inhalation of dust may cause slight respiratory irritation
Acute Toxicity: No data available on LD50 values; not known to cause acute toxicity in humans under normal laboratory use
Chronic Effects: No known long-term health hazards at levels present in laboratory reagents
Sensitization: Rare allergic reaction possible in sensitive individuals; symptoms include rash or respiratory discomfort
Ecotoxicity: Not regarded as hazardous to aquatic organisms at lab use levels; enzyme breakdown products rapidly degrade in the environment
Persistence and Degradability: Readily biodegradable, protein nature facilitates rapid decomposition by microbes
Bioaccumulation Potential: Low, proteins not expected to accumulate in organisms
Mobility in Soil: High mobility in aqueous phase, broken down by soil microorganisms
Waste Treatment Methods: Dispose of unused product and contaminated packaging through licensed waste contractor in accordance with local, regional, and national regulations
Contaminated Packaging: Rinse and dispose as chemical waste or incineration if permitted
Avoid Release: Do not discharge into sewage systems or environment
UN Number: Not regulated for transport under international regulations
Proper Shipping Name: Not assigned (non-hazardous for shipping)
Transport Hazard Class: None
Packing Group: None
Special Precautions: Protect from physical damage, keep containers sealed, avoid excessive heat during transport
Inventory Status: Registered in chemical inventories of major jurisdictions under protein preparations or enzymes
OSHA Status: Non-hazardous
TSCA: Exempt or listed for R&D use
REACH Status: Exempt as naturally-derived protein
Other Regulations: Conforms to industry standards for laboratory chemicals; not subject to special labeling or risk phrases under current regulations
Workplace Hazard Controls: Standard laboratory PPE recommended as practical measure for all protein-based reagents
