Product Name: Maropitant Citrate
Chemical Name: 2-Piperidinone, 1-[(2,3-dihydro-2-oxo-1H-benzimidazol-1-yl)methyl]-3,4-dihydro-, dihydrogen citrate
CAS Number: 158861-67-7
Recommended Use: Antiemetic agent for veterinary medicine
Manufacturer: Zoetis Inc.
Emergency Contact: Local Poison Control Center or company emergency response
Address: Listed on manufacturer’s datasheet
Telephone Number: Manufacturer’s contact number, available on product packaging
GHS Classification: Not classified as hazardous per OSHA Hazard Communication Standard
Label Elements: No pictogram, no signal word
Potential Health Effects: Dust inhalation can irritate respiratory tract; direct contact can lead to mild eye and skin irritation; not flammable under normal conditions
Precautionary Statements: Handle to minimize dust; avoid ingestion, inhalation, eye and skin contact
Environmental Hazards: No evidence of serious environmental hazard in normal veterinary use
Chemical Name: Maropitant Citrate
Concentration (%): >98%
CAS Number: 158861-67-7
Other Ingredients: Pharmaceutical excipients and carriers used in formulated products, including lactose, microcrystalline cellulose, povidone; no hazardous components present in significant amounts
General Notes: Remove from exposure; seek medical advice if symptoms develop
Inhalation: Move person to fresh air, keep comfortable for breathing
Skin Contact: Wash area with soap and water
Eye Contact: Rinse cautiously with water for at least 15 minutes; seek medical attention for persistent irritation
Ingestion: Rinse mouth with water, do not induce vomiting unless instructed by medical personnel; seek attention if adverse reaction occurs
Suitable Extinguishing Media: Water spray, carbon dioxide, dry powder, or foam
Unsuitable Extinguishing Media: None known
Specific Hazards: Emits toxic fumes under fire conditions including oxides of nitrogen and carbon
Protective Equipment: Firefighters require full protective gear and self-contained breathing apparatus
Special Procedures: Avoid breathing fumes; contain extinguishing water to prevent environmental contamination
Personal Precautions: Wear suitable protective equipment to avoid skin and eye contact
Environmental Precautions: Prevent material entering drains or watercourses
Methods for Clean-Up: Sweep up carefully to avoid dust, place in closed container for proper disposal; ventilate area and wash spill zone with water after clean-up
Precautions for Safe Handling: Use with adequate ventilation; wash hands thoroughly after handling; avoid creating dust
Storage Conditions: Store at room temperature in a tightly closed container; keep away from incompatible materials including strong acids and oxidizing agents; prevent moisture ingress
Incompatibilities: Strong oxidizers and acids can cause degradation
Occupational Exposure Limits: No established limit for maropitant citrate
Engineering Controls: Use local exhaust and general ventilation
Personal Protective Equipment: Eye protection (safety glasses or goggles), protective gloves, lab coats or other skin protection
Respiratory Protection: Respirators where risk of inhalation exists; use NIOSH-approved mask for particulates
Hygiene Measures: Wash hands before breaks and at end of shift; avoid eating or drinking in areas of use
Appearance: White to off-white crystalline powder
Odor: No strong odor
Odor Threshold: Not applicable
pH: Not available
Melting Point/Range: 124 to 127°C
Boiling Point: Decomposes before boiling
Flash Point: Not flammable
Evaporation Rate: Not applicable
Flammability: Not easily ignitable
Vapor Pressure: Negligible at room temperature
Solubility: Soluble in DMSO, sparingly soluble in water
Partition Coefficient (n-octanol/water): Not determined
Vapor Density: Not relevant for solid
Relative Density: Not determined
Autoignition Temperature: Not self-heating
Decomposition Temperature: Not established
Viscosity: Not applicable for solid substance
Chemical Stability: Stable at recommended storage conditions
Reactivity: No dangerous reactions known under normal conditions
Hazardous Reactions: Avoid exposure to strong oxidizing agents and acids
Decomposition Products: Oxides of carbon and nitrogen under fire or intensive heat
Conditions to Avoid: High heat, direct sunlight, open flames, and incompatible chemicals
Acute Toxicity (Oral): LD50 (rat) >2000 mg/kg, considered low toxicity
Skin Corrosion/Irritation: No significant irritation in animal studies
Serious Eye Damage: Mild irritation potential
Sensitization: Not shown to cause skin or respiratory sensitization in tested animals
Carcinogenicity: Not classified as carcinogen by IARC, NTP, or OSHA
Mutagenicity: Negative in standard in vitro and in vivo assays
Reproductive Toxicity: Animal data do not indicate effects on fertility or fetal development at doses used in veterinary practice
Chronic Effects: Not known to pose significant health hazard with occupational exposure under proper handling
Ecotoxicity: Shows limited toxicity to aquatic life in standard tests; low risk under current use patterns
Persistence and Degradability: Expected to be biodegradable; does not persist in soil or water long term
Bioaccumulative Potential: Low potential for bioaccumulation in organisms
Mobility in Soil: Limited mobility in soil, unlikely to contaminate groundwater when used as directed
Other Adverse Effects: No evidence of harm to birds, mammals, or beneficial soil organisms at therapeutic doses
Waste Disposal Methods: Dispose of in accordance with local, regional, and national laws; incineration preferred for bulk material; do not discharge to sewer or streams
Packaging Disposal: Rinse containers thoroughly; dispose of via licensed waste contractor
Special Precautions: Do not reuse empty containers for other products or household use; keep out of reach of children and animals
UN Number: Not regulated for transport
Proper Shipping Name: Not classified as dangerous goods
Hazard Class: Not applicable
Packing Group: Not applicable
Special Precautions: Protect from moisture and direct sunlight during transit; use original container
Safety, Health, and Environmental Regulations: Regulated under the US FDA (for animal use), and by relevant international regulations for pharmaceuticals
SARA Title III: Not subject to reporting
REACH Registration: Not required for veterinary pharmaceuticals in EU
TSCA Status: Exempt as pharmaceutical agent
Other National Requirements: Follow specific regulations in country of use for animal medical products, and occupational health rules for manufacturer employees
