Product Name: Pentoxyverine Citrate
Chemical Formula: C20H29NO7 • C6H8O7
Synonyms: Pentoxyverine hydrogen citrate, Antitussive agent
Manufacturer: Refer to product supplier’s information
Recommended Use: Cough suppressant in pharmaceutical formulations
Emergency Telephone: Use local emergency contact information
Classification: Harmful if swallowed, irritant to eyes and respiratory system
Signal Word: Warning
Hazard Statements: Causes eye and respiratory irritation, harmful if ingested
Pictograms: Exclamation mark
Precautionary Statements: Avoid contact with skin and eyes, keep container closed, wash thoroughly after handling, use only in well-ventilated areas, avoid inhalation of dust or vapor
Chemical Name: Pentoxyverine Citrate
Active Ingredient: Pentoxyverine Citrate
Concentration or Range: 98% or greater by weight
Impurities: Trace organics and inorganic salts (< 2%)
Additives: None
CAS Number: 8003-22-7 (Pentoxyverine Citrate)
Eye Contact: Rinse cautiously with water for several minutes, remove contact lenses if present, continue rinsing, seek medical attention if irritation persists
Skin Contact: Wash skin thoroughly with mild soap and water, remove contaminated clothing, seek medical help if rash or irritation occurs
Inhalation: Move victim to fresh air, keep warm and at rest, administer oxygen if breathing is difficult, call a physician
Ingestion: Rinse mouth thoroughly, do not induce vomiting, never give anything by mouth to an unconscious person, obtain medical attention immediately
Symptoms and Effects: Nausea, vomiting, dizziness, cough suppression, respiratory discomfort, may aggravate existing respiratory or allergic conditions
Suitable Extinguishing Media: Water spray, dry powder, foam, carbon dioxide
Unsuitable Extinguishing Media: High pressure water jets
Special Hazards Arising: May emit toxic fumes of carbon oxides and nitrogen oxides, dense smoke possible
Protective Equipment: Wear self-contained breathing apparatus and full protective gear
Special Procedures: Move containers from danger area if it can be done safely, avoid inhaling smoke or fumes
Personal Precautions: Ventilate area, avoid formation and inhalation of dust, wear protective gloves, goggles, and mask
Environmental Precautions: Prevent entry into drains, sewers, or watercourses, contain spill with absorbent material
Clean-Up Methods: Gather material into suitable closed containers, sweep or vacuum up spillage, wash site with soap and water after removal
Emergency Procedures: Notify management and follow established procedures for hazardous material spills
Handling: Use local exhaust ventilation in processing areas, avoid dust generation, do not breathe dust, keep container tightly closed after each use, use only with recommended personal protective measures
Storage: Store in original, sealed container in a cool, dry, well-ventilated area away from incompatible substances such as strong oxidizers and acids, protect from light, moisture, and physical damage, keep out of reach of children
Occupational Exposure Limits: No established regulatory exposure limits; minimize exposure as a precaution
Control Parameters: Monitor air for potential dust concentrations
Personal Protection: Wear appropriate safety goggles, laboratory gloves, lab coat or apron, approved respirator if dust forms
Engineering Controls: General room ventilation, local exhaust as needed
Hygiene Measures: Wash thoroughly after handling, do not eat, drink, or smoke in areas where this chemical is handled, launder contaminated clothing before reuse
Appearance: White to off-white crystalline powder
Odor: Faint, characteristic odor
Odor Threshold: Not determined
pH: 4 to 6 (1% aqueous solution)
Melting Point/Freezing Point: 155–160 °C
Initial Boiling Point and Range: Not applicable (decomposes on heating)
Flash Point: Not identified
Evaporation Rate: Not relevant
Flammability: Not flammable under normal conditions
Vapor Pressure: Negligible at standard temperature
Vapor Density: Not available
Relative Density: 1.2 - 1.4 g/cm³
Solubility: Soluble in water, ethanol; insoluble in ether
Partition Coefficient (n-octanol/water): Not available
Auto-ignition Temperature: Not determined
Decomposition Temperature: Decomposes above melting point
Chemical Stability: Stable under recommended handling and storage conditions
Reactivity: No dangerous reactions known under normal use
Possible Hazardous Reactions: Contact with strong oxidizers or strong acids may cause decomposition
Conditions to Avoid: Moisture, excessive heat, exposure to light, incompatible materials
Incompatible Materials: Strong acids, strong bases, oxidizing agents
Hazardous Decomposition Products: Carbon monoxide, carbon dioxide, nitrogen oxides, irritating fumes
Acute Toxicity: LD50 (oral, rat): approximately 1000 mg/kg (literature value)
Routes of Exposure: Ingestion, inhalation, skin, and eye contact
Symptoms: May include coughing suppression, dizziness, headache, gastrointestinal upset
Skin Corrosion/Irritation: Mild irritant
Eye Damage/Irritation: May cause mild to moderate irritation
Respiratory Sensitization: May aggravate asthma or respiratory allergies
Carcinogenicity: No components identified as carcinogenic by IARC, NTP, or OSHA
Mutagenicity: Not identified as a mutagen in standard assays
Reproductive Toxicity: No known effects
Repeated Dose Toxicity: Data limited; avoid long-term exposure
Ecotoxicity: Data limited, avoid release to the environment
Aquatic Toxicity: Harmful to aquatic organisms at high concentrations
Persistence and Degradability: Not readily biodegradable, may persist in environment
Bioaccumulative Potential: Expected to have low bioaccumulation potential
Mobility in Soil: Moderately mobile, may leach after heavy rainfall
Other Adverse Effects: Not known to produce endocrine disruption
Appropriate Disposal: Dispose of as hazardous pharmaceutical waste in accordance with local, regional, or national regulations, do not incinerate in open air, avoid discharge to natural waters
Contaminated Packaging: Triple rinse containers, perforate and dispose via licensed chemical waste handler
Disposal Methods: Contact licensed waste disposal contractor, do not reuse contaminated packaging
UN Number: Not assigned
UN Proper Shipping Name: No data available for regulation under international transport authorities
Transport Hazard Class: Not classified as dangerous goods
Packing Group: Not applicable
Environmental Hazards: Not a marine pollutant
Special Precautions for User: Prevent spillage during transit, avoid contact with food and feedstuffs, secure containers appropriately
OSHA: Not classified as hazardous under US OSHA Hazard Communication Standard
TSCA: Not listed for use under TSCA
EU Regulations: Not subject to classification under CLP Regulation (EC) No 1272/2008, pharmaceutical use only
Other National Regulations: Subject to regulations under national pharmaceutical and chemical safety standards
Label Requirements: Pharmaceutical grade, for prescription or industrial use only, not for general public sale
Specific Provisions: Comply with applicable workplace safety and product stewardship requirements
