Product Name: Piperazine Citrate
Synonyms: 1,4-Piperazine dihydrate, 1,4-Diazacyclohexane, Piperazine hexahydrate
Chemical Formula: (C4H10N2)3.C6H8O7
CAS Number: 41372-20-7
Intended Uses: Pharmaceutical deworming agent, laboratory reagent
Manufacturer Information: Provided on request, listed on primary MSDS
Emergency Contact Phone: Refer to local country chemical emergency contacts
Recommended Restrictions: Only for professional, medical, or laboratory use
GHS Classification: Not considered a hazardous substance for supply or transport but can cause irritation
Signal Word: Warning
Hazard Statements: May cause skin, eye, or respiratory irritation upon contact or inhalation
Pictograms: Exclamation mark symbol for irritant properties
Precautionary Statements: Avoid breathing dust, wash hands thoroughly after handling, wear protective gloves and eyewear, discard contaminated clothing, do not eat or drink during use, avoid environmental release
Symptoms of Exposure: Sneezing, sore throat, redness of eyes or skin, stomach pain if ingested in large amounts
Chemical Name: Piperazine Citrate
Concentration: 100% (active pharmaceutical ingredient)
Impurities: Not known to contain significant impurities; toxicological properties based on pure substance
Molecular Weight: 485.54 g/mol
Component CAS Numbers: 4620-70-6 (piperazine), 77-92-9 (citric acid)
General Advice: Move affected person to fresh air if inhalation occurs, remove contaminated clothing
Skin Contact: Wash skin with soap and plenty of water, seek medical attention if irritation develops
Eye Contact: Rinse cautiously with water for several minutes, remove contact lenses if present, get medical help if irritation persists
Inhalation: Move person to fresh air, keep comfortable for breathing, seek medical attention if symptoms continue
Ingestion: Rinse mouth, never give anything by mouth to an unconscious person, contact poison control center or physician immediately
Special Notes: Treat symptomatically, medical staff should use appropriate PPE during response
Suitable Extinguishing Media: Use water spray, alcohol-resistant foam, dry chemical powder, or carbon dioxide
Unsuitable Extinguishing Media: Do not use high pressure streams, risk of spreading dust
Specific Hazards: During combustion, may produce toxic fumes including nitrogen oxides and carbon oxides
Special Firefighting Instructions: Wear full protective gear and self-contained breathing apparatus, prevent fire-fighting water from entering drains
Explosion Data: No explosive properties known; avoid creating dust in confined spaces
Hazardous Combustion Products: Carbon monoxide, carbon dioxide, nitrogen oxides
Personal Precautions: Evacuate unprotected personnel, ventilate area, avoid inhalation of dust or aerosols, use appropriate PPE (gloves, goggles, dust mask)
Environmental Precautions: Prevent further leakage or spillage, avoid discharge to drains, water courses, and soil
Methods for Cleanup: Scoop up to a clean, dry container for proper disposal, wipe area with damp cloth, wash spill site with water after material pick-up is complete
Disposal of Decontamination Materials: Collect wipes and cleaning cloths for proper disposal as hazardous waste
Safe Handling: Wear personal protective equipment including gloves and goggles, wash hands after handling, avoid generation and inhalation of dusts, use local exhaust ventilation or fume hood
Storage Requirements: Store in tightly closed containers in a cool, dry, well-ventilated place away from strong acids and oxidizers
Incompatibilities: Avoid storing near strong acids, strong oxidizers, and moisture
Other Recommendations: Keep away from food and drink, keep out of reach of children and unauthorized personnel, label properly
Exposure Limits: Not established for piperazine citrate specifically, observe general dust limits (e.g., OSHA PEL for particulates not otherwise regulated: 15 mg/m³)
Engineering Controls: Use local exhaust ventilation, enclosed processes where feasible
Personal Protective Equipment: Gloves (nitrile or latex), safety goggles, laboratory coat, dust mask or respirator if ventilation inadequate
Hygiene Measures: Remove contaminated clothing, wash hands thoroughly after handling, no eating or drinking in work area
Appearance: White, crystalline powder
Odor: Odorless
pH: 5-7 (in aqueous solution)
Melting Point: Decomposes above 190°C
Boiling Point: Not applicable (decomposes before boiling)
Solubility: Soluble in water
Vapor Pressure: Not applicable
Density: 1.6 g/cm³
Partition Coefficient (n-octanol/water): Not available
Evaporation Rate: Not available
Flammability: Not considered flammable under normal conditions
Other Properties: Hygroscopic, absorbs moisture from air
Chemical Stability: Stable under recommended storage conditions
Decomposition: Decomposes on heating, with release of irritating gases
Hazardous Reactions: Reacts with strong acids to produce salts, reacts with oxidizers
Conditions to Avoid: Moisture, strong heat, contact with strong acids or oxidizing agents
Polymerization: No dangerous polymerization expected
Acute Toxicity: LD50 (oral, rat): >2,000 mg/kg (as piperazine base)
Sensitization: Not a known skin sensitizer in humans
Chronic Exposure: Prolonged or repeated exposure may cause gastrointestinal symptoms, dizziness, or headache
Carcinogenicity: Not listed as a carcinogen by IARC, OSHA, or NTP
Other Effects: Possible effects on nervous system and liver at high doses
Routes of Exposure: Inhalation, ingestion, skin, eye contact
Ecotoxicity: No comprehensive data available, low acute toxicity to aquatic life expected due to low environmental persistence
Persistence and Degradability: May degrade slowly in the environment; no significant bioaccumulation anticipated
Mobility in Soil: Expected to be mobile in water due to solubility
Aquatic Toxicity: No significant effect on aquatic organisms observed in available studies, but large quantities should not enter environment
Bioaccumulation Potential: Not expected to bioaccumulate
Waste Treatment Methods: Dispose of in accordance with local, regional, and national regulations
Product Waste: Collect and send to approved chemical waste facility
Contaminated Packaging: Rinse empty containers with water, dispose of as hazardous chemical waste
Special Precautions: Do not allow product or waste water to enter drains, sewers, or watercourses
Reduction of Waste: Keep quantities used minimal, re-use where practical
UN Number: Not classified as a dangerous good for transport
Transportation Hazard Class: Non-hazardous
Packing Group: Not assigned
Proper Shipping Name: Piperazine Citrate
Special Precautions: Transport in original container, keep upright and secure to prevent spillage
Environmental Hazards: Not a marine pollutant
Classification: Not classified as hazardous under major global systems (OSHA, GHS, EU CLP)
TSCA Status: Listed
REACH Status: Registered or exempt
Other Regulations: Subject to workplace safety standards including training, labeling, storage, and personal protection measures
Inventory Lists: Listed on US TSCA, EU EINECS/ELINCS, Australian AICS, Canadian DSL, Japanese ENCS
SARA 313: Not listed
California Proposition 65: Not listed as known to cause cancer or reproductive toxicity
