Product Name: Tri-n-butyl Citrate
Chemical Formula: C18H32O7
Synonyms: Tributyl 2-hydroxypropane-1,2,3-tricarboxylate, Tributyl Citrate, TBC
CAS Number: 77-94-1
Recommended Use: Plasticizer, solvent in cosmetics, and food packaging
Supplier Information: Contact details for manufacturer or distributor, including emergency contact number and address for quick response in case of incident
GHS Classification: Not classified as hazardous under GHS criteria
Signal Word: None
Hazard Statements: May cause mild irritation to eyes and skin on contact
Precautionary Statements: Use only with adequate ventilation, wash hands after handling, avoid direct contact with skin and eyes
Routes of Exposure: Inhalation, ingestion, skin and eye contact
Health Hazards: Prolonged or repeated exposure can cause dryness of skin or irritation, ingestion in large quantities could upset digestive tract
Environmental Hazards: Spills could impact aquatic environments if not contained and cleaned up promptly
Chemical Name: Tri-n-butyl Citrate
Concentration: Typically >99% pure
Impurities: Small amounts of butyl alcohols and other citrate esters may be present as trace impurities
Other Ingredients: No hazardous additives commonly reported in commercial grades
Inhalation: Move affected person to fresh air, keep comfortable and observe for symptoms such as dizziness or headache, seek medical advice if symptoms persist
Skin Contact: Wash with plenty of soap and water, remove contaminated clothing, seek attention if irritation develops and continues
Eye Contact: Rinse cautiously with water for several minutes, remove contact lenses if present and easy to do, continue rinsing and get medical help if irritation occurs
Ingestion: Rinse mouth with water, do not induce vomiting unless instructed by medical personnel, seek medical attention if large amounts swallowed or if feeling unwell
Suitable Extinguishing Media: Dry chemical, carbon dioxide, alcohol-resistant foam, or water spray can be used for small fires
Unsuitable Media: Direct stream of water may spread liquid
Specific Hazards: In a fire, material can produce irritating or toxic fumes such as carbon monoxide and carbon dioxide
Special Protective Equipment: Firefighters should wear self-contained breathing apparatus (SCBA) and full protective gear
Fire Fighting Instructions: Move containers away from the fire area if safe, cool containers exposed to heat with water spray, prevent runoff from entering drains
Personal Precautions: Evacuate area, provide proper ventilation, avoid breathing vapors, wear suitable protective equipment including gloves and goggles
Environmental Precautions: Prevent spills from entering waterways and soil, contain spill using sand, earth, or an approved absorbent
Cleanup Methods: Collect with absorbent material and place in properly labeled chemical waste containers, wash spill area with water and detergent to remove residues, dispose of in accordance with local regulations
Handling: Work in a well-ventilated area, avoid inhalation of vapors and contact with skin or eyes, use proper personal protective equipment, keep away from food and beverages
Storage Conditions: Store in tightly closed containers in a dry, cool, and well-ventilated area, keep away from strong acids, bases, and oxidizing agents, protect containers from damage and direct sunlight, label and store separately from incompatible materials
Occupational Exposure Limits: No established exposure limit values for tri-n-butyl citrate, but best practice suggests keeping exposure as low as possible
Engineering Controls: Ensure good general ventilation, provide local exhaust at points of emission
Personal Protection: Wear suitable chemical-resistant gloves, safety goggles, and protective clothing to reduce risk of skin or eye contact; use respiratory protection where ventilation is inadequate or exposure limits are exceeded; wash hands after handling and before eating, drinking, or smoking
Appearance: Clear, colorless or slightly yellow oily liquid
Odor: Mild, characteristic
Odor Threshold: Not determined
pH: Not available (insoluble in water)
Melting Point: -20°C
Boiling Point: 324°C at 101.3 kPa
Flash Point: Around 199°C (closed cup)
Evaporation Rate: Very low
Flammability: Not classified as flammable but may burn at high temperature
Vapor Pressure: <0.01 hPa at 20°C
Density: 1.05 g/cm³ at 20°C
Solubility: Slightly soluble in water, soluble in alcohols and many organic solvents
Partition Coefficient (n-octanol/water): log Kow approximately 4.0
Auto-Ignition Temperature: 430°C
Decomposition Temperature: Not established
Viscosity: About 32 mPa·s at 25°C
Stability: Stable under recommended storage and normal conditions of use
Reactivity: Non-reactive with most chemicals during general use
Conditions to Avoid: Excessive heat, open flames, exposure to strong oxidizers, acids, or bases
Incompatible Materials: Strong oxidizing agents, strong acids and bases
Hazardous Decomposition Products: Combustion or thermal decomposition can produce carbon monoxide, carbon dioxide, and other unidentified organic compounds
Acute Toxicity: Oral LD50 (rat): >30,000 mg/kg, indicating low acute toxicity
Skin Irritation: Mild irritation possible after prolonged exposure
Eye Irritation: Mild transient irritation
Respiratory Sensitization: No data suggests respiratory sensitization
Skin Sensitization: Not expected to cause allergic skin reactions
Chronic Toxicity: Studies on chronic exposure do not show significant adverse effects
Carcinogenicity: Not classed as carcinogen by IARC, NTP, or OSHA
Mutagenicity: No evidence from available data
Reproductive Toxicity: Some studies have reported limited reproductive effects in extremely high doses not relevant to usual human exposures
Environmental Fate: Biodegradable under aerobic conditions, expected to degrade in soil and water over time
Aquatic Toxicity: LC50 (fish, 96h): 54 mg/L; LC50 (daphnia, 48h): >49 mg/L
Persistence and Degradability: Readily biodegradable according to OECD guidelines
Bioaccumulation Potential: Potential for bioaccumulation due to a moderate log Kow, actual accumulation in aquatic life is not significant at expected environmental concentrations
Mobility in Soil: Low volatility, binds to soil particles
Other Adverse Effects: No significant ozone depletion or global warming impact identified
Disposal Methods: Recover and recycle if possible, otherwise dispose of through licensed chemical waste contractors
Contaminated Packaging: Empty containers should be rinsed to remove residues, then sent for recycling or disposal in accordance with local and national regulations
Special Precautions: Do not release into sewers, surface waters or soil, report any significant releases to local authorities as required
UN Number: Not regulated as a hazardous material for transport
UN Proper Shipping Name: Not required
Transport Hazard Class: Not applicable
Packing Group: Not applicable
Labels: No hazardous labels required
Special Precautions for User: Use tightly sealed containers during transport, avoid extreme temperatures and ensure secure placement to prevent leaks or spills
Inventory Listings: Listed in TSCA (US), EINECS/ELINCS (Europe), DSL (Canada), ENCS (Japan), AICS (Australia), and other major chemical inventories
Regulatory Status: Not classified as hazardous under US OSHA, European REACH, or other primary regulatory frameworks
REACH Registration Number: Available upon request for suppliers under European law
Other Applicable Regulations: Subject to inspection and reporting under chemical control and environmental regulations in regions of manufacturing and use, safety data must accompany every shipment for workplace safety
Labelling Requirements: Workplace containers must carry proper labels with product identification and hazard communication information even though not formally classified as hazardous
