Product Name: Trimethoprim Lactate
Chemical Formula: C14H18N4O3.C3H6O3
Synonyms: Trimethoprim, 2,4-diamino-5-(3,4,5-trimethoxybenzyl)pyrimidine lactate salt
Recommended Use: Pharmaceutical ingredient, antibacterial agent
Manufacturer: [Company Name, Address, Phone Number]
Emergency Phone Number: [24-hour number for chemical emergencies]
GHS Classification: Harmful if swallowed (Acute Tox Oral Cat 4), Eye irritation (Cat 2A), Skin irritation (Cat 2)
Pictograms: Exclamation mark
Signal Word: Warning
Hazard Statements: Causes eye irritation. Causes skin irritation. Harmful if swallowed. May cause allergic skin reaction.
Precautionary Statements: Wash hands thoroughly after handling. Wear protective gloves and eye protection. Do not eat, drink or smoke while using product. If in eyes, rinse cautiously with water for several minutes.
Chemical Name: Trimethoprim Lactate
CAS Number: 738-70-5 (Trimethoprim), 79-33-4 (Lactic Acid)
Concentration: Trimethoprim 75-85%; Lactic Acid 15-25%
Impurities: Residual solvents, unreacted starting materials under 1%
Other Ingredients: None reported
Inhalation: Remove exposed individual to fresh air. Seek medical attention for any respiratory distress.
Skin Contact: Remove contaminated clothing immediately, rinse skin thoroughly with water and soap. Get medical advice for rash or persistent irritation.
Eye Contact: Rinse eyes cautiously with water for several minutes. Remove contact lenses if present. Seek medical attention for eye pain or vision changes.
Ingestion: If swallowed, rinse mouth, do not induce vomiting unless directed by medical personnel. Call poison control or physician immediately.
Suitable Extinguishing Media: Use water spray, dry chemical, carbon dioxide, or foam.
Unsuitable Extinguishing Media: Do not use high pressure water stream due to risk of spreading powder.
Specific Hazards: Emits toxic fumes of carbon oxides and nitrogen oxides during combustion.
Protective Equipment: Firefighters should wear full protective clothing and self-contained breathing apparatus.
Special Procedures: Avoid runoff to water bodies. Cool exposed containers with water spray.
Personal Risks: Avoid breathing dust. Prevent skin and eye contact.
Methods for Cleaning: Sweep up spill without creating dust. Place in suitable containers for disposal. Ventilate area.
Environmental Precautions: Avoid entry into drains, sewers and waterways. Report releases as required by standard regulations.
Decontamination: Wash contaminated area with water and mild detergent after material removal.
Handling: Handle only in well-ventilated areas. Use local exhaust. Wear appropriate personal protection. Avoid contact with skin, eyes and clothing.
Storage: Store in original tight containers away from direct sunlight. Keep at temperature between 15°-25°C. Keep separate from food and feed.
Incompatible Materials: Strong oxidizers, reducing agents, strong acids or bases.
Special requirements: Store away from children and unauthorized individuals.
Occupational Exposure Limits: No established limits. Minimize exposure as much as possible.
Engineering Controls: Use with local exhaust ventilation and containment as necessary.
Personal Protective Equipment: Chemical-resistant gloves, lab coat or apron, eye protection (goggles or safety glasses). Use an approved dust respirator if airborne exposure risk exists.
Hygiene: Wash hands and face after working with material and before eating, drinking, or smoking. Do not wear contaminated clothing outside the work area.
Appearance: White to pale yellow crystalline powder
Odor: No characteristic odor
Odor Threshold: Data not available
pH: Slightly acidic aqueous solution
Melting Point: Decomposes above 210°C
Boiling Point: Not applicable
Flash Point: Not determined
Flammability: Not highly flammable
Solubility: Sparingly soluble in water, more soluble in methanol, ethanol
Vapor Pressure: Negligible at room temperature
Partition Coefficient (log Kow): 0.91 (trimethoprim) approx.
Chemical Stability: Stable under normal conditions of storage and use.
Reactivity: Not reactive with most materials under standard use.
Hazardous Reactions: Contact with strong acids, bases and oxidizers may produce hazardous decomposition.
Decomposition Products: Carbon oxides, nitrogen oxides, possible formaldehyde on thermal decomposition.
Conditions to Avoid: High heat, open flame, incompatible materials, direct sunlight for extended periods.
Acute Toxicity: Oral LD50 (rat) approximately 1300-1600 mg/kg (trimethoprim component).
Skin Corrosion/Irritation: Brief skin contact may cause mild irritation.
Serious Eye Damage/Irritation: Causes temporary eye irritation.
Respiratory Sensitization: Prolonged or repeated inhalation may trigger respiratory symptoms.
Skin Sensitization: May cause allergic skin reactions in susceptible individuals.
Carcinogenicity: Not listed as a carcinogen by IARC, NTP, or OSHA.
Other Data: Large doses may cause blood dyscrasias, rash, or gastrointestinal symptoms.
Ecotoxicity: Harmful to aquatic organisms at higher concentrations.
Persistence and Degradability: Biodegrades slowly in soil and water.
Bioaccumulation: Low bioaccumulation potential.
Mobility in Soil: Moderate mobility due to partial water solubility.
Other Adverse Effects: Disruption of microbial activity in soil or water not excluded.
Waste Treatment Methods: Collect and place in suitable sealed containers for disposal according to local, state, and federal regulations.
Disposal of Packaging: Treat contaminated packaging as hazardous material; rinse and discard as per official guidance.
Environmental Warning: Do not release to sewer or natural water sources.
Additional Info: Contact authorized chemical waste disposal contractor for all bulk wastes.
UN Number: Not classified as hazardous for transport by ground, air, or sea
Proper Shipping Name: Not regulated
Transport Hazard Class: Not applicable
Packing Group: Not applicable
Environmental Hazards: Not considered a marine pollutant
Special Precautions: Avoid rough handling, keep containers tightly sealed to prevent spillage
Safety, Health and Environmental Regulations: OSHA Hazard Communication Standard (29 CFR 1910.1200): Not classified as a hazardous chemical. SARA Title III Section 313: Not listed. California Proposition 65: Not listed. TSCA Inventory: Components appear on the list.
International Inventory Listings: Trimethoprim appears on European EINECS, Canadian DSL, Australian AICS.
Labeling Requirements: GHS compliant labeling recommended for packaging.
Workplace Restrictions: Follow all workplace exposure standards and pharmacovigilance recommendations.
Other Regulatory Info: Check specific country or region requirements for pharmaceutical substances.
