Product Name: Tripotassium Citrate Monohydrate
Synonyms: Potassium Citrate, 1,2,3-Propanetricarboxylic acid, 2-hydroxy-, tripotassium salt, monohydrate
Chemical Formula: C6H5K3O7·H2O
CAS Number: 6100-05-6
EC Number: 212-755-5
Relevant Use: Food additive, pharmaceutical excipient, buffer agent, laboratory reagent
Manufacturer Contact: Information for emergency, safety, and further advice should be provided directly by the supplier or manufacturer
Classification: This chemical does not meet hazardous classification under GHS for most routine industrial and laboratory uses
Physical Hazards: The substance will not burn easily; unlikely to present a physical hazard under normal storage and handling
Health Hazards: Large doses may cause mild gastrointestinal upset, such as nausea or diarrhea; breathing dust can cause mild respiratory irritation
Environmental Hazards: Not considered dangerous for the environment in standard use, but large spills could disrupt soil or aquatic nutrient balances
Label Elements: Not classified as hazardous, so precautionary pictograms are not required
Other Hazards: Potential for dust explosions in closed spaces if dust accumulates alongside ignition sources
Chemical Name: Tripotassium Citrate Monohydrate
Concentration: 100%
Molecular Weight: 324.41 g/mol (monohydrate)
Impurities or Stabilizing Additives: No significant impurities identified in commercially pure samples
Composition Comments: Complex mixtures are unlikely; users should expect primarily the monohydrate form unless otherwise noted on label
Eye Contact: Flush eyes thoroughly with water for several minutes; seek medical attention if irritation persists
Skin Contact: Remove contaminated clothing and rinse skin with plenty of water; seek medical advice if redness or discomfort occurs
Inhalation: Move person to fresh air; obtain medical advice if any breathing problems develop
Ingestion: Rinse mouth and drink water; avoid inducing vomiting unless instructed by medical personnel; obtain medical attention for large exposures or if gut upset persists
Advice for Medical Responders: Provide symptomatic and supportive care as needed; no specific antidote known
Suitable Extinguishing Media: Water spray, dry chemical, carbon dioxide, or foam
Unsuitable Extinguishing Media: Avoid high-pressure water jets that may create dust clouds
Hazardous Combustion Products: Potassium oxides and carbon oxides may form if fire breaks out in large quantities
Protective Equipment: Full protective clothing and approved self-contained breathing apparatus are recommended for large fires
Special Firefighting Procedures: Move containers away from fire if safe; keep loads cool with water spray; minimize dust dispersal during efforts
Personal Precautions: Avoid making dust; use personal protective gear including dust masks, gloves, goggles as appropriate
Environmental Precautions: Prevent large spills from entering drains, surface water, or soil directly
Cleanup Methods: Sweep up gently and collect in suitable waste containers; clean trace residues with water; ventilate the area to remove residual dust
Reference to Other Sections: Follow disposal guidance and personal protection recommendations in relevant sections
Safe Handling: Minimize dust formation; use adequate ventilation; avoid inhalation or direct contact; implement dust control where necessary
Hygiene Measures: Wash hands after handling, before eating, drinking, or using bathroom facilities
Storage Conditions: Store in tightly closed containers in cool, dry locations away from incompatible materials (such as strong acids)
Storage Temperature: Protect from excessive heat and humidity; avoid exposure to moisture that may cause caking or degradation
Packaging Materials: Store in containers that resist corrosion and moisture penetration
Occupational Exposure Limits: No specific limits set by OSHA, ACGIH, or NIOSH
Engineering Controls: Use general exhaust ventilation, and if necessary, local exhaust to prevent buildup of airborne dust
Personal Protective Equipment: Safety goggles or glasses for eye protection, gloves for skin protection, and dust masks or respirators for respiratory protection in dusty environments
Environmental Exposure Controls: Prevent uncontrolled releases to drainage systems or outdoor soil; collect spilled material properly
Appearance: White, crystalline powder or granules
Odor: Odorless
Odor Threshold: Not applicable
pH: Strongly alkaline in water solution (8.5–10 at 5% w/v)
Melting Point: Decomposes before melting at approximately 230°C
Boiling Point: Not applicable (decomposes)
Flash Point: Not flammable
Evaporation Rate: Not applicable
Flammability: Not classified as flammable; forms combustible dusts
Vapor Pressure: Not applicable
Vapor Density: Not applicable
Solubility: Easily soluble in water (approx. 630 g/L at 20°C)
Partition Coefficient (n-octanol/water): Not established
Autoignition Temperature: No data available
Decomposition Temperature: Over 230°C
Viscosity: Not applicable
Bulk Density: Around 900–1100 kg/m³
Chemical Stability: Stable under normal storage and handling conditions
Reactivity: Non-reactive under recommended use; avoid strong acids which may release citric acid and potassium salts
Conditions to Avoid: Heat, moisture, and dust formation
Incompatible Materials: Strong acids, oxidizing agents
Hazardous Decomposition Products: Potassium oxide, carbon monoxide, and carbon dioxide may form under fire or high heat
Acute Toxicity: Oral LD50 (rat) above 5000 mg/kg; considered low toxicity
Skin Corrosion/Irritation: Not expected to irritate intact skin
Serious Eye Damage/Irritation: Eye contact with powder or concentrated solution may cause mild, temporary irritation
Respiratory Sensitization: Not classified as a respiratory sensitizer
Skin Sensitization: Not classified as a skin sensitizer
Germ Cell Mutagenicity: Not identified as mutagenic based on available data
Carcinogenicity: Not listed by IARC, NTP, or OSHA
Reproductive Toxicity: No effects observed in animal studies at relevant exposure levels
STOT - Single Exposure: Not expected to cause organ toxicity from single exposure
STOT - Repeated Exposure: No evidence of adverse health effects from chronic low-level exposure
Aspiration Hazard: Not applicable
Ecotoxicity: Not expected to harm aquatic organisms at typical concentrations; readily dilutes and dissociates in water
Persistence and Degradability: Readily biodegradable; citrates and potassium ions naturally present in the environment
Bioaccumulative Potential: Not expected to bioaccumulate, based on water solubility and rapid biodegradation
Mobility in Soil: High mobility due to water solubility
Other Adverse Effects: Large spills can increase nutrient loading in water bodies, potentially causing mild eutrophication if uncontained
Waste Treatment Methods: Dispose according to federal, state, and local regulations; small quantities can be diluted with plenty of water and disposed of in regular sewage systems unless prohibited
Product Disposal: Collect and send to approved chemical disposal facility when disposing of bulk material
Container Disposal: Triple rinse containers and offer for recycling or follow local procedures for solid chemical waste
UN Number: Not classified as hazardous for transport
Proper Shipping Name: Not regulated
Transport Hazard Class: Not assigned
Packing Group: Not assigned
Environmental Hazards: None
Special Precautions: Keep containers secure and minimize damage during shipping
TSCA Inventory (US): Listed
REACH Status (EU): Registered or exempted
FDA/EU Food Additive: Approved as a food additive
SARA 313 (US): Not subject to reporting
California Proposition 65: Not listed
WHMIS Classification (Canada): Not subject to classification as a hazardous chemical
Other Regulations: Product complies with regional and national requirements for its intended uses as an ingredient or laboratory agent, but local use or discharge restrictions may apply
