Product Name: Trisodium Citrate Dihydrate
Synonyms: Citrosodine, Sodium Citrate Tribasic Dihydrate
Chemical Formula: C6H5Na3O7·2H2O
Recommended Use: Food additive, buffering agent, anticoagulant in blood collection, cleaning agent
CAS Number: 6132-04-3
Manufacturer Contact: Refer to supplier label for updated manufacturer and emergency telephone information
GHS Classification: Not classified as a hazardous substance under GHS regulations
Signal Word: None
Hazard Statements: May cause mild skin and eye irritation in susceptible individuals
Precautionary Statements: Avoid contact with eyes and prolonged skin exposure; use with adequate ventilation; keep container tightly closed
Pictograms: None required under standard conditions
Potential Health Effects: Skin contact may produce dryness; ingestion in large amounts could upset stomach; dust particles can irritate mucous membranes
Chemical Name: Trisodium Citrate Dihydrate
Common Name: Sodium Citrate
CAS Number: 6132-04-3
Percent (%): 99-100% by weight
Impurities: Water of hydration; trace inorganic salts below regulatory thresholds
Eye Contact: Rinse with gentle flow of water for several minutes; remove contact lenses if present; continue rinsing
Skin Contact: Wash with soap and plenty of water; remove contaminated clothing and wash before use
Inhalation: Move to fresh air; support breathing as necessary; seek medical attention if symptoms such as coughing or difficulty breathing occur
Ingestion: Rinse mouth with water; drink small amounts of water; seek medical advice only if large quantities get swallowed or symptoms persist
Most Important Symptoms: Mild irritation to mucous membranes; dryness or discomfort of skin; transient gastric upset on ingestion
Note to Physician: Treat symptomatically; product has low toxicity profile
Suitable Extinguishing Media: Water spray, dry chemical, foam, or carbon dioxide
Specific Hazards: Trisodium citrate dihydrate does not burn but may decompose at high temperatures; burning produces sodium oxides and irritating fumes
Protection for Firefighters: Wear self-contained breathing apparatus; use protective clothing to avoid skin and eye exposure to thermal decomposition products
Special Precautions: Move containers from fire area if it can be done without risk; maintain safe distance if risk of hazardous decomposition exists
Personal Precautions: Use dust mask, goggles, and gloves to minimize contact
Environmental Precautions: Avoid large quantities from entering drains, sewers, or watercourses; notify authorities if spillage contaminates large bodies of water
Methods for Cleanup: Sweep up or vacuum spilled material; avoid raising dust; transfer to a suitable container for disposal; wash spill area with water
Handling: Work in well-ventilated areas; minimize dust generation; avoid contact with eyes and skin; wash hands after use
Storage Conditions: Store in tightly closed containers; keep in a cool, dry, well-ventilated space, away from moisture and incompatible substances such as strong acids
Other Precautions: Keep container labeled; restrict access to trained personnel; avoid eating, drinking, or smoking in the storage area
Occupational Exposure Limits: No established limits for trisodium citrate dihydrate
Engineering Controls: General room ventilation; local exhaust to minimize airborne dust when handling bulk product
Personal Protective Equipment: Safety goggles, protective gloves, dust mask or respirator for high-dust environments, lab coat or coveralls
Hygiene Measures: Wash hands after handling; remove contaminated clothing before eating or drinking; keep work area clean
Appearance: White crystalline powder
Odor: Odorless
pH (1% solution): Approximately 7.5–9.0
Melting Point: Decomposes above 150°C
Solubility: Highly soluble in water; insoluble in alcohol
Relative Density: 1.76 g/cm3
Boiling Point: Not applicable (decomposes)
Flash Point: Not flammable
Vapor Pressure: Negligible at ambient temperature
Partition Coefficient (n-octanol/water): No data available
Evaporation Rate: Not volatile
Chemical Stability: Stable under normal conditions of storage and use
Possibility of Hazardous Reactions: None under standard handling; reacts with strong acids, producing citric acid and possible gas release
Conditions to Avoid: Excess moisture; excessive heat; contact with strong acids
Incompatible Materials: Strong acids, strong oxidizers
Hazardous Decomposition Products: Sodium oxides, carbon oxides, irritating vapors when heated strongly or on contact with strong acids
Acute Toxicity: Low toxicity expected; oral LD50 (rat): >5,000 mg/kg
Irritation: Mild irritation to eyes, skin, and respiratory tract with dust exposure
Sensitization: Not reported to cause sensitization
Chronic Effects: No evidence of chronic or cumulative health effects from routine exposure
Carcinogenicity: Not classified as carcinogenic by IARC, OSHA, or NTP
Mutagenicity: No evidence of mutagenic activity in standard assays
Reproductive Toxicity: Not expected to cause reproductive or developmental effects under normal use
Ecotoxicity: Expected to have low toxicity to aquatic organisms in natural concentrations; large releases may affect aquatic pH
Persistence and Degradability: Readily biodegradable; citrate ion breaks down in the environment
Bioaccumulation: Not anticipated to bioaccumulate in aquatic species
Mobility in Soil: High water solubility; may move readily through soil with water
Other Adverse Effects: Large-scale discharges could temporarily increase salinity and alkalinity in local ecosystems
Waste Treatment Methods: Dispose of according to local, regional, national, and international regulations
Product Disposal: Small amounts can go to sanitary landfill or dissolve in water and flush into approved drain with plenty of water
Container Disposal: Rinse and recycle containers where appropriate; otherwise, follow local disposal regulations for chemical wastes
Special Precautions: Prevent contamination of surface and ground water during disposal
UN Number: Not regulated as hazardous for transport
UN Proper Shipping Name: Not applicable
Transport Hazard Class(es): Not classified
Packing Group: Not assigned
Environmental Hazards: None identified for routine shipments
Transport in bulk: Follow general rules for non-hazardous materials
Safety, Health and Environmental Regulations: Not listed by US OSHA, EU REACH as hazardous; approved as a food additive in many countries
TSCA Inventory (US): Listed
EINECS (EU): Listed (200-675-3)
Food Additive Code: E331
SARA Title III: Not subject to SARA reporting requirements
Other Information: Product label and accompanying documentation provide reference to further details and up-to-date regulatory information
