Enclomiphene citrate emerges as a notable nonsteroidal selective estrogen receptor modulator, frequently referenced as an isomer within the clomiphene family. With its white to off-white crystalline appearance, this powdered raw material stands out through its defined flake-like structure and moderate density. Usually delivered as a finely granulated substance rather than large aggregates, the raw material resists common moisture absorption, limiting clumping and supporting a dry, free-flowing texture. Examination in the lab demonstrates stability at room temperature, though storage below 25°C preserves its quality for extended periods. With a formula of C26H28ClNO·C6H8O7, the compound presents as a structured, complex molecule, and this complexity continues through to its action and utility in research and pharmaceutical development.
Enclomiphene Citrate features a molecular weight approaching 598.09 g/mol, placing it near the upper range for small-molecule modulators. Solid at room temperature, neither flammable nor especially volatile, the compound’s density sits between 1.2–1.3 g/cm³, aligning with many organic citrates. Its solubility favors alcohols and certain organic solvents while offering only partial dispersion in water, a point requiring careful preparation for any solution-based use. Whether processed as flakes, fine powder, compacted pearls, or occasional crystalline grains, the physical form reflects both production methods and intended use. Under microscopy, the structure reveals sharp-edged, prismatic crystals rather than amorphous masses, hinting at high purity and proper crystallization during synthesis. Handling pure enclomiphene citrate, even in material science or pharmaceutical settings, means respecting its chemical specificity and reactivity—not for exposure to open flame or mixing with incompatible acids or oxidizers.
Diagramming the structure highlights enclomiphene’s triphenylethylene backbone, similar to its molecular cousins in therapeutic classes targeting endocrine modulation. The addition of a chloride and intricate aromatic rings signals the molecule’s capacity to interact with biological targets, particularly within the estrogen receptor environment. The molecular formula guides chemists on precise molar calculations, doesn't just sit as background knowledge—it’s critical for dosing, formulation, and regulatory compliance in lab and clinical situations. For those tracking shipments or compiling import documents, the HS Code for enclomiphene citrate tracks under 2937290000, making international trade transparent and traceable. Material Safety Data Sheets for this compound cite moderate acute toxicity if ingested or inhaled, as well as possible irritant qualities, requiring gloves, protective eyewear, and ventilation for any significant manipulation or weighing.
Anyone working directly with enclomiphene citrate keeps in mind its chemical risks. Although not considered highly hazardous under standard classification, direct ingestion, inhalation of dust, or repeated skin contact bring risks of harm. Proper chemical safety training means storing it in tightly sealed, labeled containers, away from acids, oxidizers, and sources of heat or light. Lab experience insists on using analytical balances for portioning, glass scoops to avoid static, and careful use of fume hoods for weighing and solution preparation. Waste must pass through approved solvent and solid chemical routes, rather than drain disposal, reflecting its active organic nature. Beyond hazards, the professionalism of approach makes itself known in avoiding cross-contamination—each batch deserves clean spatulas, washed glassware, and up-to-date calibration on analytical equipment.
Most often, enclomiphene citrate ships as a solid—flaked or powdered. In some pharmaceutical or chemical research settings, a solution in ethanol or DMSO appears for easier dosing or incorporation into other liquid systems. I’ve handled solutions of this class and found their light sensitivity a recurring concern: brown glass ampoules keep the active agent from breaking down under fluorescent laboratory lighting. Even when stored as a dry crystalline mass, changes in humidity shift the cohesion of the flakes; silica desiccants help maintain consistent handling characteristics. The industry leans heavily on accurate volumetric and gravimetric techniques, especially during dissolution into specific concentrations needed for dosing or further chemical modification.
Across research, enclomiphene citrate operates as a valuable raw material in endocrine, fertility, and hormonal studies. The compound’s defined structure and high purity make it critical for both clinical trials and in vitro experimentation, as results frequently rely on reproducible compound quality. Any deviation in molecular weight, structure, or purity brings the risk of unreliable data, wasted batches, or regulatory complications. Close adherence to storage, handling, and transport rules—including full documentation of the HS code, molecular formula, lot number, and supplier data—ensures the traceability. Regular in-house quality control checks back up the paperwork, confirming identity through techniques like NMR, HPLC, and melting point assays. The safety profile, while moderate, still means ongoing training, PPE investment, and written protocols for any facilities making routine use of the compound. Each of these factors—chemical purity, physical properties, responsible handling, and full regulatory visibility—builds trust with collaborators, customers, and the scientific community relying on accurate, reproducible results.
